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Table 2 Univariate analysis of prognostic factors of 294 patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

From: Unresected small lymph node assessment predicts prognosis for patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

Variable TR (%) χ P LR (%) χ P DM (%) χ P OS (%) χ P
3-year 5-year 3-year 5-year 3-year 5-year 3-year 5-year
Sex    0.189 0.664    0.002 0.962    0.505 0.477    1.616 0.204
 Male 40.7 48.5    31.0 40.1    20.4 21.8    67.7 58.3   
 Female 36.4 47.0    30.6 39.4    14.6 25.9    75.1 71.2   
Age (years)    0.046 0.830    0.361 0.548    0.513 0.474    0.002 0.962
 <60 40.3 44.1    34.0 38.2    16.8 19.1    67.7 62.3   
 ≥60 39.4 53.8    28.3 44.0    21.5 25.7    71.4 59.4   
Tumor location    2.180 0.336    1.485 0.476    2.570 0.277    1.092 0.579
 Upper thoracic region 42.8 47.6    37.5 42.7    13.1 20.4    73.3 67.3   
 Middle thoracic region 42.3 50.5    31.1 39.6    24.1 27.6    64.7 60.3   
 Lower thoracic region 28.7 42.2    22.5 37.2    12.6 12.6    76.9 57.2   
Surgical approach    0.127 0.722    0.007 0.933    0.015 0.903    0.437 0.509
 Ivor–Lewis 40.0 51.0    28.3 41.4    19.9 21.9    67.2 56.0   
 McKeown 38.8 45.6    32.7 37.9    18.6 23.7    71.0 66.0   
Length of tumor    0.103 0.748    1.937 0.164    0.930 0.335    0.130 0.719
 <4 cm 40.8 49.4    34.8 44.2    18.0 20.1    69.8 59.7   
 ≥4 cm 38.4 46.5    25.8 34.0    20.7 25.7    69.1 62.0   
Angioinvasion    0.011 0.916    0.048 0.826    0.725 0.394    0.005 0.945
 No 39.9 47.7    30.9 40.4    19.0 22.6    69.6 60.8   
 Yes 37.9 37.9    31.5 31.5    21.5 21.5    67.1 67.1   
Perineural invasion    0.004 0.947    0.063 0.802    0.092 0.761    1.010 0.315
 No 39.3 48.9    30.7 40.9    19.0 22.9    71.4 61.9   
 Yes 41.1 41.1    31.8 31.8    19.5 19.5    61.0 61.0   
No. of removed LNs    5.417 0.020*    4.866 0.027*    1.375 0.241    4.951 0.026*
 <15 46.2 64.1    33.5 55.7    25.9 33.8    62.4 50.0   
 ≥15 36.9 40.0    29.7 32.2    16.4 17.7    72.4 66.4   
No. of dissected LN stations    2.335 0.126    1.827 0.176    0.888 0.346    1.718 0.190
 <6 43.9 61.9    31.0 53.1    25.0 32.0    66.8 52.1   
 ≥6 37.8 40.2    30.9 32.4    16.5 17.9    70.5 66.8   
Tumor grade    8.299 0.016*    8.654 0.013*    4.274 0.118    7.385 0.025*
 Well-differentiated 28.9 45.0    14.5 31.2    18.7 27.0    77.3 67.2   
 Moderately differentiated 36.0 41.4    30.6 36.4    14.9 14.9    72.3 65.4   
 Poorly differentiated 52.1 59.1    42.6 51.0    25.8 29.9    59.8 51.1   
Adjuvant therapy    20.708 <0.001*    18.589 <0.001*    6.774 0.034*    11.007 0.004*
 No 54.8 66.1    46.7 58.0    25.7 38.1    60.1 48.6   
 Chemotherapy 27.9 36.6    20.4 30.0    13.5 13.5    77.1 69.8   
 Radiotherapy/chemoradiotherapy 24.3 35.1    9.3 22.3    20.7 32.0    73.8 63.3   
Unresected small LNs status    13.511 <0.001*    15.375 <0.001*    2.368 0.124    10.382 0.001*
 CT-negative 33.7 38.8    25.6 30.4    15.3 18.7    74.8 68.8   
 CT-suspect 54.3 70.9    44.1 64.4    29.9 29.9    56.3 42.5   
  1. TR total recurrence; LR locoregional recurrence; DM distant metastasis; OS overall survival; CT computed tomography; LN lymph node
  2. *P value < 0.05