Variable
|
TR (%)
|
χ
|
P
|
LR (%)
|
χ
|
P
|
DM (%)
|
χ
|
P
|
OS (%)
|
χ
|
P
|
---|
3-year
|
5-year
|
3-year
|
5-year
|
3-year
|
5-year
|
3-year
|
5-year
|
---|
Sex
| | |
0.189
|
0.664
| | |
0.002
|
0.962
| | |
0.505
|
0.477
| | |
1.616
|
0.204
|
Male
|
40.7
|
48.5
| | |
31.0
|
40.1
| | |
20.4
|
21.8
| | |
67.7
|
58.3
| | |
Female
|
36.4
|
47.0
| | |
30.6
|
39.4
| | |
14.6
|
25.9
| | |
75.1
|
71.2
| | |
Age (years)
| | |
0.046
|
0.830
| | |
0.361
|
0.548
| | |
0.513
|
0.474
| | |
0.002
|
0.962
|
<60
|
40.3
|
44.1
| | |
34.0
|
38.2
| | |
16.8
|
19.1
| | |
67.7
|
62.3
| | |
≥60
|
39.4
|
53.8
| | |
28.3
|
44.0
| | |
21.5
|
25.7
| | |
71.4
|
59.4
| | |
Tumor location
| | |
2.180
|
0.336
| | |
1.485
|
0.476
| | |
2.570
|
0.277
| | |
1.092
|
0.579
|
Upper thoracic region
|
42.8
|
47.6
| | |
37.5
|
42.7
| | |
13.1
|
20.4
| | |
73.3
|
67.3
| | |
Middle thoracic region
|
42.3
|
50.5
| | |
31.1
|
39.6
| | |
24.1
|
27.6
| | |
64.7
|
60.3
| | |
Lower thoracic region
|
28.7
|
42.2
| | |
22.5
|
37.2
| | |
12.6
|
12.6
| | |
76.9
|
57.2
| | |
Surgical approach
| | |
0.127
|
0.722
| | |
0.007
|
0.933
| | |
0.015
|
0.903
| | |
0.437
|
0.509
|
Ivor–Lewis
|
40.0
|
51.0
| | |
28.3
|
41.4
| | |
19.9
|
21.9
| | |
67.2
|
56.0
| | |
McKeown
|
38.8
|
45.6
| | |
32.7
|
37.9
| | |
18.6
|
23.7
| | |
71.0
|
66.0
| | |
Length of tumor
| | |
0.103
|
0.748
| | |
1.937
|
0.164
| | |
0.930
|
0.335
| | |
0.130
|
0.719
|
<4 cm
|
40.8
|
49.4
| | |
34.8
|
44.2
| | |
18.0
|
20.1
| | |
69.8
|
59.7
| | |
≥4 cm
|
38.4
|
46.5
| | |
25.8
|
34.0
| | |
20.7
|
25.7
| | |
69.1
|
62.0
| | |
Angioinvasion
| | |
0.011
|
0.916
| | |
0.048
|
0.826
| | |
0.725
|
0.394
| | |
0.005
|
0.945
|
No
|
39.9
|
47.7
| | |
30.9
|
40.4
| | |
19.0
|
22.6
| | |
69.6
|
60.8
| | |
Yes
|
37.9
|
37.9
| | |
31.5
|
31.5
| | |
21.5
|
21.5
| | |
67.1
|
67.1
| | |
Perineural invasion
| | |
0.004
|
0.947
| | |
0.063
|
0.802
| | |
0.092
|
0.761
| | |
1.010
|
0.315
|
No
|
39.3
|
48.9
| | |
30.7
|
40.9
| | |
19.0
|
22.9
| | |
71.4
|
61.9
| | |
Yes
|
41.1
|
41.1
| | |
31.8
|
31.8
| | |
19.5
|
19.5
| | |
61.0
|
61.0
| | |
No. of removed LNs
| | |
5.417
|
0.020*
| | |
4.866
|
0.027*
| | |
1.375
|
0.241
| | |
4.951
|
0.026*
|
<15
|
46.2
|
64.1
| | |
33.5
|
55.7
| | |
25.9
|
33.8
| | |
62.4
|
50.0
| | |
≥15
|
36.9
|
40.0
| | |
29.7
|
32.2
| | |
16.4
|
17.7
| | |
72.4
|
66.4
| | |
No. of dissected LN stations
| | |
2.335
|
0.126
| | |
1.827
|
0.176
| | |
0.888
|
0.346
| | |
1.718
|
0.190
|
<6
|
43.9
|
61.9
| | |
31.0
|
53.1
| | |
25.0
|
32.0
| | |
66.8
|
52.1
| | |
≥6
|
37.8
|
40.2
| | |
30.9
|
32.4
| | |
16.5
|
17.9
| | |
70.5
|
66.8
| | |
Tumor grade
| | |
8.299
|
0.016*
| | |
8.654
|
0.013*
| | |
4.274
|
0.118
| | |
7.385
|
0.025*
|
Well-differentiated
|
28.9
|
45.0
| | |
14.5
|
31.2
| | |
18.7
|
27.0
| | |
77.3
|
67.2
| | |
Moderately differentiated
|
36.0
|
41.4
| | |
30.6
|
36.4
| | |
14.9
|
14.9
| | |
72.3
|
65.4
| | |
Poorly differentiated
|
52.1
|
59.1
| | |
42.6
|
51.0
| | |
25.8
|
29.9
| | |
59.8
|
51.1
| | |
Adjuvant therapy
| | |
20.708
|
<0.001*
| | |
18.589
|
<0.001*
| | |
6.774
|
0.034*
| | |
11.007
|
0.004*
|
No
|
54.8
|
66.1
| | |
46.7
|
58.0
| | |
25.7
|
38.1
| | |
60.1
|
48.6
| | |
Chemotherapy
|
27.9
|
36.6
| | |
20.4
|
30.0
| | |
13.5
|
13.5
| | |
77.1
|
69.8
| | |
Radiotherapy/chemoradiotherapy
|
24.3
|
35.1
| | |
9.3
|
22.3
| | |
20.7
|
32.0
| | |
73.8
|
63.3
| | |
Unresected small LNs status
| | |
13.511
|
<0.001*
| | |
15.375
|
<0.001*
| | |
2.368
|
0.124
| | |
10.382
|
0.001*
|
CT-negative
|
33.7
|
38.8
| | |
25.6
|
30.4
| | |
15.3
|
18.7
| | |
74.8
|
68.8
| | |
CT-suspect
|
54.3
|
70.9
| | |
44.1
|
64.4
| | |
29.9
|
29.9
| | |
56.3
|
42.5
| | |
- TR total recurrence; LR locoregional recurrence; DM distant metastasis; OS overall survival; CT computed tomography; LN lymph node
- *P value < 0.05