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Table 2 Univariate analysis of prognostic factors of 294 patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

From: Unresected small lymph node assessment predicts prognosis for patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

Variable

TR (%)

χ

P

LR (%)

χ

P

DM (%)

χ

P

OS (%)

χ

P

3-year

5-year

3-year

5-year

3-year

5-year

3-year

5-year

Sex

  

0.189

0.664

  

0.002

0.962

  

0.505

0.477

  

1.616

0.204

 Male

40.7

48.5

  

31.0

40.1

  

20.4

21.8

  

67.7

58.3

  

 Female

36.4

47.0

  

30.6

39.4

  

14.6

25.9

  

75.1

71.2

  

Age (years)

  

0.046

0.830

  

0.361

0.548

  

0.513

0.474

  

0.002

0.962

 <60

40.3

44.1

  

34.0

38.2

  

16.8

19.1

  

67.7

62.3

  

 ≥60

39.4

53.8

  

28.3

44.0

  

21.5

25.7

  

71.4

59.4

  

Tumor location

  

2.180

0.336

  

1.485

0.476

  

2.570

0.277

  

1.092

0.579

 Upper thoracic region

42.8

47.6

  

37.5

42.7

  

13.1

20.4

  

73.3

67.3

  

 Middle thoracic region

42.3

50.5

  

31.1

39.6

  

24.1

27.6

  

64.7

60.3

  

 Lower thoracic region

28.7

42.2

  

22.5

37.2

  

12.6

12.6

  

76.9

57.2

  

Surgical approach

  

0.127

0.722

  

0.007

0.933

  

0.015

0.903

  

0.437

0.509

 Ivor–Lewis

40.0

51.0

  

28.3

41.4

  

19.9

21.9

  

67.2

56.0

  

 McKeown

38.8

45.6

  

32.7

37.9

  

18.6

23.7

  

71.0

66.0

  

Length of tumor

  

0.103

0.748

  

1.937

0.164

  

0.930

0.335

  

0.130

0.719

 <4 cm

40.8

49.4

  

34.8

44.2

  

18.0

20.1

  

69.8

59.7

  

 ≥4 cm

38.4

46.5

  

25.8

34.0

  

20.7

25.7

  

69.1

62.0

  

Angioinvasion

  

0.011

0.916

  

0.048

0.826

  

0.725

0.394

  

0.005

0.945

 No

39.9

47.7

  

30.9

40.4

  

19.0

22.6

  

69.6

60.8

  

 Yes

37.9

37.9

  

31.5

31.5

  

21.5

21.5

  

67.1

67.1

  

Perineural invasion

  

0.004

0.947

  

0.063

0.802

  

0.092

0.761

  

1.010

0.315

 No

39.3

48.9

  

30.7

40.9

  

19.0

22.9

  

71.4

61.9

  

 Yes

41.1

41.1

  

31.8

31.8

  

19.5

19.5

  

61.0

61.0

  

No. of removed LNs

  

5.417

0.020*

  

4.866

0.027*

  

1.375

0.241

  

4.951

0.026*

 <15

46.2

64.1

  

33.5

55.7

  

25.9

33.8

  

62.4

50.0

  

 ≥15

36.9

40.0

  

29.7

32.2

  

16.4

17.7

  

72.4

66.4

  

No. of dissected LN stations

  

2.335

0.126

  

1.827

0.176

  

0.888

0.346

  

1.718

0.190

 <6

43.9

61.9

  

31.0

53.1

  

25.0

32.0

  

66.8

52.1

  

 ≥6

37.8

40.2

  

30.9

32.4

  

16.5

17.9

  

70.5

66.8

  

Tumor grade

  

8.299

0.016*

  

8.654

0.013*

  

4.274

0.118

  

7.385

0.025*

 Well-differentiated

28.9

45.0

  

14.5

31.2

  

18.7

27.0

  

77.3

67.2

  

 Moderately differentiated

36.0

41.4

  

30.6

36.4

  

14.9

14.9

  

72.3

65.4

  

 Poorly differentiated

52.1

59.1

  

42.6

51.0

  

25.8

29.9

  

59.8

51.1

  

Adjuvant therapy

  

20.708

<0.001*

  

18.589

<0.001*

  

6.774

0.034*

  

11.007

0.004*

 No

54.8

66.1

  

46.7

58.0

  

25.7

38.1

  

60.1

48.6

  

 Chemotherapy

27.9

36.6

  

20.4

30.0

  

13.5

13.5

  

77.1

69.8

  

 Radiotherapy/chemoradiotherapy

24.3

35.1

  

9.3

22.3

  

20.7

32.0

  

73.8

63.3

  

Unresected small LNs status

  

13.511

<0.001*

  

15.375

<0.001*

  

2.368

0.124

  

10.382

0.001*

 CT-negative

33.7

38.8

  

25.6

30.4

  

15.3

18.7

  

74.8

68.8

  

 CT-suspect

54.3

70.9

  

44.1

64.4

  

29.9

29.9

  

56.3

42.5

  
  1. TR total recurrence; LR locoregional recurrence; DM distant metastasis; OS overall survival; CT computed tomography; LN lymph node
  2. *P value < 0.05