Adverse events | Studies involved | Event/total | % |
---|---|---|---|
Hematological system AEs | |||
 Neutropenia | 2 | 229/254 | 90.16 |
 Anemia | 4 | 174/327 | 53.21 |
 Platelet count decrease | 2 | 91/261 | 34.87 |
 WBC count decrease | 4 | 91/346 | 26.30 |
 Febrile neutropenia | 2 | 7/66 | 10.61 |
Digestive system AEs | |||
 Dysphagia | 2 | 30/73 | 41.96 |
 Esophagitis | 2 | 25/73 | 32.89 |
 Nausea | 5 | 118/363 | 32.51 |
 Constipation | 4 | 83/332 | 25.00 |
 Decreased appetite | 1 | 67/228 | 29.39 |
 Diarrhea | 5 | 76/363 | 20.94 |
 Vomiting | 2 | 40/254 | 15.75 |
 Increased aspartate transaminase level | 1 | 6/45 | 13.33 |
 Norexia | 3 | 13/99 | 13.13 |
 Abdominal pain | 1 | 5/45 | 11.11 |
 Stomatitis | 1 | 1/26 | 3.85 |
 Duodenitis | 1 | 1/40 | 2.50 |
 Pancreatitis | 1 | 1/40 | 2.50 |
Respiratory system AEs | |||
 Dyspnea | 4 | 76/346 | 21.97 |
 Pneumonia | 3 | 53/294 | 18.03 |
 Lung infection | 1 | 5/40 | 12.50 |
 Respiratory failure | 1 | 1/40 | 2.50 |
Skin AEs | |||
 Rash | 6 | 51/396 | 12.88 |
 Pruritus | 5 | 46/372 | 12.37 |
 Dry skin | 1 | 2/24 | 8.33 |
 Excessive tearing | 1 | 2/24 | 8.33 |
 Radiation dermatitis | 2 | 6/73 | 8.22 |
Circulative system AEs | |||
 Peripheral edema | 2 | 22/268 | 8.21 |
 Pericarditis | 1 | 1/40 | 2.50 |
 Sinus tachycardia | 1 | 1/40 | 2.50 |
 Flushing | 1 | 1/40 | 2.50 |
Nervous system AEs | |||
 Peripheral sensory neuropathy | 2 | 17/66 | 25.76 |
 Peripheral motor neuropathy | 1 | 3/26 | 11.54 |
 Neuropathy | 1 | 5/45 | 11.11 |
Motor system AEs | |||
 Myalgia | 2 | 12/50 | 24.00 |
 Arthralgia | 2 | 10/64 | 15.63 |
 Back pain | 2 | 33/273 | 12.09 |
 Arthritis | 1 | 2/40 | 5.00 |
 Muscle weakness | 1 | 1/33 | 3.03 |
 Chest wall pain | 1 | 1/40 | 2.50 |
Electrolyte disturbance AEs | |||
 Hyponatremia | 3 | 32/294 | 10.88 |
 Hypokalemia | 1 | 3/40 | 7.50 |
Urological system AEs | |||
 Creatinine increased | 1 | 9/40 | 22.50 |
 Chronic kidney disease | 1 | 2/40 | 5.00 |
Endocrine system AEs | |||
 Type I diabetes mellitus | 1 | 3/26 | 11.54 |
 Hypothyroidism | 2 | 24/254 | 9.49 |
Systemic AEs | |||
 Fatigue | 5 | 121/370 | 32.70 |
 Asthenia | 3 | 58/278 | 20.86 |
 Pyrexia | 1 | 35/228 | 15.35 |
 Generalized weakness | 1 | 5/45 | 11.11 |
Others AEs | |||
 Alopecia | 1 | 75/228 | 32.89 |
 Cough | 4 | 71/346 | 20.52 |
 Dizziness | 3 | 48/229 | 16.05 |
 Noncardiac chest pain | 1 | 6/45 | 13.33 |
 Headache | 4 | 39/332 | 11.75 |
 Insomnia | 2 | 27/252 | 10.71 |
 Pain | 1 | 3/33 | 9.09 |
 Confusion | 1 | 1/40 | 2.50 |