Table 2 Correlation of cytomorphologic pathological character and the response to crizotinib in ALK-positive NSCLC patients
Cytomorphologic pathological features | ORR (%) P value | P value | DCR (%) | |
|---|---|---|---|---|
Signet ring cells | Â | 0.019 | Â | 0.032 |
Yes (N = 21) | 57.1% (12/21) | Â | 71.4% (15/21) | Â |
No (N =39) | 84.6% (33/39) | Â | 94.9% (37/39) | Â |
Extracellular mucin | Â | 0.631 | Â | 0.806 |
Yes (N = 19) | 68.4% (13/19) | Â | 84.2% (16/19) | Â |
No (N = 41) | 78.0% (32/41) | Â | 90.2% (37/41) | Â |
Cribriform pattern | Â | 0.264 | Â | 0.393 |
Yes (N = 12) | 58.3% (7/12) | Â | 75% (9/12) | Â |
No (N = 48) | 79.2% (38/48) | Â | 89.6% (43/48) | Â |