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Table 3 Univariate and multivariate analysis results of risk factors related to POPF after PD (2005 ISGPF edition)

From: Establishment of risk prediction model of postoperative pancreatic fistula after pancreatoduodenectomy: 2016 edition of definition and grading system of pancreatic fistula: a single center experience with 223 cases

Variable Univariate analysis Multivariate analysis
Odds ratio 95% CI P value Odds ratio 95% CI P value
Sex (male / female) 1.389 0.648–2.977 0.398    
Age ( 65 years/<65 years) 0.837 0.392–1.790 0.647    
Body mass index (23/<23) 1.597 0.767–3.328 0.210    
Drinking habit (yes/no) 0.935 0.378–2.314 0.884    
Smoking habit (yes/no) 1.131 0.557–2.299 0.733    
Diabetes mellitus (yes/no) 0.595 0.253–1.403 0.233    
Main pancreatic duct diameter (< 3 mm/≥ 3 mm) 6.464 2.956–14.136 0.000 4.210 1.399–12.669 0.011
Main pancreatic duct index (<0.21/≥ 0.21) 5.532 2.563–11.943 0.000 4.561 1.480–14.059 0.008
Portal vein invasiona (no/yes) 10.000 1.226–81.534 0.024    
Intra-abdominal thicknessb (≥ 69 mm/< 69 mm) 3.083 1.482–6.412 0.002    
Preoperative biliary drainage (no/yes) 3.612 1.095–11.913 0.027    
Pancreatic cancer (no/yes) 2.687 1.110–6.507 0.025 5.517 1.546–19.688 0.009
Pancreatic resection margin thickness ( 15 mm/< 15 mm) 2.200 1.058–4.573 0.032    
Pancreas CT value (< 39 HU/ 39 HU) 2.681 1.297–5.541 0.007 8.981 2.934–27.490 0.000
White blood cell count ( 9.5×109/L/< 9.5×109/L) 0.678 0.109–4.205 0.675    
Albumin (< 40 g/L/ 40 g/L) 1.395 0.686–2.838 0.358    
Total bilirubin ( 20 μmol/L/<20 μmol/L) 1.857 0.717–4.813 0.199    
Amylase (< 110 IU/L/ 110 IU/L) 0.206 0.042–0.999 0.033    
CA19-9 (< 39 U/mL/ 39 U/mL) 2.096 0.929–4.729 0.112    
Pancreaticojejunostomy (dunking method/duct-to-mucosa) 0.960 0.404–2.280 0.926    
  1. Continuous variables were classified into two groups as follows: The thresholds of body mass index, main pancreatic duct diameter, main pancreatic duct index, intra-abdominal thickness, pancreatic resection margin thickness, and pancreas CT value were determined based on the median value of each parameter. All laboratory data were divided based on the upper or lower limit of normal range of each parameter
  2. POPF postoperative pancreatic fistula, PD pancreatoduodenectomy, ISGPF International Study Group of Pancreatic Fistula, CI confidence
  3. interval, CT computed tomographic scan, CA19-9 carbohydrate antigen 19-9
  4. aThe tumors that were not attached, compressed, or obviously involved the portal and/or superior mesenteric veins on CT
  5. bMeasured as the distance from the internal face of rectus abdominis (linea alba) to the rear wall of the aorta at the level of the umbilicus