Fig. 3

Circ_0018289 targeted miR-183-5p. A Sequence of miR-183-5p, the complementary sites for miR-183-5p in circ_0018289, and the mutant of the seed sites. B qRT-PCR analysis of miR-183-5p in miR-183-5p mimic- or miR-NC mimic-transfected SiHa and HeLa cells. C Dual-luciferase reporter assays using circ_0018289 wild-type (circ_0018289-WT) or mutant-type (circ_0018289-MUT) reporter constructs in SiHa and HeLa cells. D qRT-PCR analysis of miR-183-5p in si-circ_0018289- or si-NC-transfected SiHa and HeLa cells. E qRT-PCR analysis showing the expression of miR-183-5p in 50 primary tumor samples and 50 paired normal tissues from the same patients. F Relative miR-183-5p expression in Ect1/E6E7, SiHa and HeLa cells by qRT-PCR analysis. G Correlation between circ_0018289 and miR-183-5p levels in tumor samples analyzed by Pearson’s correlation coefficients. *P < 0.05