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Fig. 5 | World Journal of Surgical Oncology

Fig. 5

From: miR-381-3p suppresses breast cancer progression by inhibition of epithelial–mesenchymal transition

Fig. 5

miR-381-3p reduces TGF-β signaling activation in breast cancer. A The expression of TGFB1 and TGFB2 in MDA-MB-231 cells transfected with miR-381-3p mimics or negative control was examined by qRT-PCR. B The expression of p-Smad2 and Smad2/3 in MDA-MB-231 or SKBR3 cells transfected with miR-381-3p mimics or negative control was examined by western blot. C Cell invasion in MDA-MB-231 cells transfected with miR-381-3p mimics or negative control after TGFβ1 addition was assessed by transwell analysis. D The expression of E-cadherin, N-cadherin, or Vimentin in MDA-MB-231 cells transfected with miR-381-3p mimics or negative control after TGFβ1 addition was examined by western blot. E The expression of TGFB1 and TGFB2 in MDA-MB-231 cells transfected with siRNAs targeting Sox4 or Twist1, as well as a negative control, was examined by qRT-PCR. *P < 0.05

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