Total mastectomy versus partial mastectomy (BCS) | Lymph node surgery versus no surgery | |||||
---|---|---|---|---|---|---|
Pre-OP DCIS (N = 682) | Total mastectomy N = 430 | Partial mastectomy N = 252 | P value | No LN surgery N = 62 | With LN surgery N = 620 | P value |
Age, year | 51.9 ± 9.9 | 53.1 ± 10.5 | 0.14 | 54 ± 12.2 | 52.2 ± 9.9 | 0.17 |
Location | 0.33 | 0.31 | ||||
Right | 213(49.5) | 115(45.6) | 26(41.9) | 302(48.7) | ||
Left | 217(50.5) | 137(54.4) | 36(58.1) | 318(51.3) | ||
Biopsy method | N/A = 3 | N/A = 0 |  < 0.01 | N/A = 0 | N/A = 3 |  < 0.01 |
CNB | 298(69.8) | 123(48.8) | 19(30.6) | 402(65.2) | ||
Stereotactic biopsy | 84(19.7) | 83(32.9) | 23(37.1) | 144(23.3) | ||
Excisional biopsy | 43(10.1) | 45(17.9) | 18(29) | 70(11.3) | ||
MMG | 2(0.5) | 1(0.4) | 2(3.2) | 1(0.2) | ||
Sonogram tumor size, cm | 2.2 ± 1.2 | 1.6 ± 0.8 |  < 0.01 | 1.7 ± 1.4 | 2 ± 1.1 | 0.11 |
Mammogram tumor size, cm | 2.9 ± 1.3 | 2.0 ± 0.9 |  < 0.01 | 1.6 ± 0.4 | 2.6 ± 1.2 | 0.10 |
MRI tumor size, cm | 4.5 ± 2.3 | 2.8 ± 1.4 |  < 0.01 | 2.7 ± 1.7 | 4 ± 2.2 |  < 0.01 |
Pathology tumor sizea, cm (cm) | 2.6 ± 2.9 | 1.7 ± 1.6 |  < 0.01 | 1.8 ± 1.7 | 2.3 ± 2.6 | 0.22 |
Gross tumor size, cmb (invasive + non-invasive) | 4 ± 2.6 | 2.2 ± 1.4 |  < 0.01 | 2.6 ± 1.8 | 3.5 ± 2.4 | 0.04 |
Stage | N/A = 11 | N/A = 22 |  < 0.01 | N/A = 12 | N/A = 21 | 0.03 |
0 | 226(53.9) | 164(71.3) | 40(80) | 350(58.4) | ||
I | 130(31) | 53(23) | 8(16) | 175(29.2) | ||
II | 54(12.9) | 11(4.8) | 2(4) | 63(10.5) | ||
III | 9(2.1) | 2(0.9) | 0(0) | 11(1.8) | ||
Grade | N/A = 38 | N/A = 36 |  < 0.01 | N/A = 19 | N/A = 55 | 0.14 |
I | 39(9.9) | 37(17.1) | 6(14.0) | 70(12.4) | ||
II | 215(54.8) | 122(56.5) | 29(67.4) | 308(54.5) | ||
III | 138(35.2) | 57(26.4) | 8(18.6) | 187(33.1) | ||
ER | N/A = 9 | N/A = 15 |  < 0.01 | N/A = 11 | N/A = 13 | 0.25 |
Positive | 293(69.6) | 191(80.6) | 41(80.4) | 443(73.0) | ||
Negative | 128(30.4) | 46(19.4) | 10(19.6) | 164(27.0) | ||
PR | N/A = 13 | N/A = 20 |  < 0.01 | N/A = 11 | N/A = 22 | 0.15 |
Positive | 259(62.1) | 179(77.2) | 39(76.5) | 399(66.7) | ||
Negative | 158(37.9) | 53(22.8) | 12(23.5) | 199(33.3) | ||
HER-2(N/A = 203) | N/A = 121 | N/A = 82 | 0.53 | N/A = 29 | N/A = 174 | 0.64 |
Positive | 118(38.2) | 60(35.3) | 11(33.3) | 167(37.4) | ||
Negative | 191(61.8) | 110(64.7) | 22(66.7) | 279(62.6) | ||
Subtype | N/A = 68 | N/A = 52 |  < 0.01 | N/A = 24 | N/A = 96 | 0.17 |
Luminal A | 198(54.7) | 133(66.5) | 27(71.1) | 304(58.0) | ||
Luminal B1 | 23(6.4) | 11(5.5) | 2(5.3) | 32(6.1) | ||
Luminal B2 | 50(13.8) | 32(16.0) | 7(18.4) | 75(14.3) | ||
HER-2( +) | 56(15.5) | 15(7.5) | 2(5.3) | 69(13.2) | ||
TNBC | 35(9.7) | 9(4.5) | 0(0) | 44(8.4) | ||
Post-OP pathology |  < 0.01 |  < 0.01 | ||||
DCIS | 255(59.3) | 194(77) | 52(83.9) | 397(64) | ||
Upgrade | 175(40.7) | 58(23) | 10(16.1) | 223(36) | ||
Ki-67 | N/A = 313 | N/A = 221 |  < 0.01 | N/A = 57 | N/A = 477 | 0.92 |
≦ 20 | 67(57.3) | 25(80.6) | 3(60) | 89(62.2) | ||
 > 20 | 50(42.7) | 6(19.4)) | 2(40) | 54(37.8) | ||
MRI LN metastasis | NA = 166 | N/A = 109 |  < 0.05 | NA = 28 | N/A = 247 | 0.10 |
Yes | 69(26.1) | 25(17.5) | 30(88.2) | 90(24.1) | ||
No | 195(73.9) | 118(82.5) | 4(11.8) | 283(75.9) | ||
Lymph node stage | N/A = 60 | N/A = 23 |  < 0.01 | N/A = 15 | N/A = 68 | 0.20 |
N0 | 327(88.4) | 222(96.9) | 47(100) | 502(90.9) | ||
N1 | 35(9.5) | 5(2.2)) | 0(0) | 40(7.2) | ||
N2 | 6(1.6) | 1(0.4) | 0(0) | 7(1.3) | ||
N3 | 2(0.5) | 1(0.4) | 0(0) | 3(0.5) | ||
LN metastasis | N/A = 8 | N/A = 25 |  < 0.01 | N/A = 29 | N/A = 4 | 0.09 |
Yes | 42(10) | 7(3.1) | 0(0) | 49(8) | ||
No | 380(90) | 220(96.9) | 33(100) | 567(92) | ||
OP method | – | – | – |  < 0.01 | ||
Total | – | – | – | 16(25.8) | 414(66.8) | |
Partial | – | – | – | 46(74.2) | 206(33.2) | |
Method LN |  < 0.01 | – | – | – | ||
SLNB | 350(81.4) | 178(70.6) | – | – | – | |
SLNB + ALND | 31(7.2) | 18(7.1) | – | – | – | |
ALND | 33(7.7) | 10(4) | – | – | – | |
ND | 16(3.7) | 46(18.3) | – | – | – |