Table 1 Relationship between demographic and clinicopathologic characteristics and FARI in patients with intrahepatic cholangiocarcinoma
Characteristic | Total (n = 394) | FARI-high (n = 168) | FARI-low (n = 226) | P value |
|---|---|---|---|---|
Age in years, median (IQR) | 59 (50–65) | 60 (52–65) | 58 (49–65.8) | 0.577 |
Male sex | 191 (48.5) | 82 (48.8) | 109 (48.2) | 0.909 |
HBsAg positive | 94 (23.9) | 35 (20.8) | 59 (26.1) | 0.206 |
Ascites | 51 (12.9) | 25 (14.9) | 26 (11.5) | 0.323 |
TBIL [μmol/l], mean (SD) | 19.2 (39.3) | 24.0 (57.7) | 15.6 (14.1) | 0.022 |
ALP [U/l], mean (SD) | 148.7 (142.2) | 191.0 (185.2) | 117.3 (87.1) | < 0.001 |
ALB [g/l], mean (SD) | 42.1 (4.3) | 39.9 (4.5) | 43.7 (3.3) | < 0.001 |
CA19-9 | ||||
 < 22 | 113 (28.7) | 38 (25.6) | 75 (33.2) | 0.022 |
 ≥ 22 | 281 (71.3) | 130 (74.4) | 151 (66.8) | |
Tumor size | ||||
 ≤ 5 cm | 148 (37.6) | 42 (25) | 89 (39.4) | 0.003 |
 > 5 cm | 246 (62.4) | 126 (75) | 137 (60.6) | |
Solitary tumor | 291 (73.9) | 117 (69.6) | 174 (76.9) | 0.533 |
Macrovascular invasion | 60 (15.2) | 30 (17.9) | 30 (17.9) | 0.211 |
Microvascular invasion | 46 (11.7) | 19 (11.3) | 27 (16.1) | 0.846 |
Cirrhosis | 38 (9.6) | 17 (10.1) | 21 (12.5) | 0.735 |
Tumor differentiation | ||||
 Poor | 287 (72.8) | 129 (76.8) | 158 (69.9) | 0.129 |
 Moderate/well | 107 (27.2) | 39 (23.2) | 68 (30.1) | |
NLR | ||||
 High | 268 (68.0) | 141 (62.4) | 127 (75.6) | < 0.001 |
 Low | 126 (31.9) | 27 (11.9) | 99 (58.9) | |
GLR | ||||
 High | 191 (48.5) | 100 (44.2) | 91 (54.2) | < 0.001 |
 Low | 203 (51.5) | 68 (30.1) | 135 (80.4) | |
AAPR | ||||
 High | 169 (42.9) | 32 (12.2) | 137 (81.5) | < 0.001 |
 Low | 225 (57.1) | 136 (60.2) | 89 (52.9) | |