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Table 2 Relationships between central lymph node metastasis mutation and clinicopathologic characteristics of 943 patients with PTC

From: Predicting factors of central lymph node metastasis and BRAFV600E mutation in Chinese population with papillary thyroid carcinoma

Variable

Overall PTC(n = 943)

PTC > 10 mm(n = 373)

PTMC(n = 570)

Yes

No

Uni- and multivariate analysis

Yes

No

Uni- and multivariate analysis

Yes

No

Uni- and multivariate analysis

n(%)

n(%)

P

P

OR(95CI)

n(%)

n(%)

P

P

OR(95CI)

n(%)

n(%)

P

P

OR(95CI)

Gender

 Male

166(71)

67(29)

< 0.001

< 0.001

0.41 (0.28–0.58)

90(84)

17(16)

0.004

0.02

0.48 (0.26–0.88)

76(60)

50(40)

< 0.001

< 0.001

0.37 (0.24–0.57)

 Female

339(48)

371(52)

185(70)

81(30)

154(35)

290(65)

Age (years) *

43.6 ± 12.2

47.2 ± 9.8

< 0.001

< 0.001

0.97 (0.96–0.98)

43.4 ± 12.6

49.2 ± 9.1

< 0.001

< 0.001

0.96 (0.94–0.98)

43.9 ± 11.7

46.6 ± 10.0

0.001

0.01

0.98 (0.96–0.99)

Tumor size (mm)*

1.5 ± 1.1

0.9 ± 0.7

< 0.001

< 0.001

3.45 (2.48–4.79)

2.1 ± 0.8

1.8 ± 0.8

0.01

0.02

1.49 (1.08–2.06)

0.7 ± 0.2

0.6 ± 0.2

0.002

0.002

3.65 (1.62–8.21)

Focality

 Uni

355(52)

333(48)

0.055

  

186(72)

73(28)

0.206

  

169(39)

260(61)

0.417

  

 Multi

150(59)

105(41)

  

89(78)

25(22)

  

61(43)

80(57)

  

HT

 No

491(55)

402(45)

< 0.001

0.03

0.42 (0.19–0.91)

270(75)

88(25)

< 0.001

0.006

0.21 (0.07–0.64)

221(41)

314(59)

0.068

  

 Yes

14(28)

36(72)

5(33)

10(67)

9(26)

26(74)

  

T staging

 T1

418(50)

420(50)

< 0.001

< 0.001

4.94 (2.84–8.59)

188(70)

80(30)

0.01

0.723

 

230(40)

340(60)

–

  

 T2 + T3

87(83)

18(17)

87(83)

18(17)

 

0

0

  

BRAFV600E mutation

 No

75(62)

62(38)

0.742

  

51(82)

11(17)

0.095

  

25(40)

50(60)

0.121

  

 Yes

430(36)

376(64)

  

224(72)

87(28)

  

205(41)

290(59)

  
  1. Abbreviations: PTC papillary thyroid carcinoma, PTMC papillary thyroid microcarcinoma, HT Hashimoto’s thyroiditis, CLNM central lymph node metastasis
  2. *Numbers are presented as means ± standard deviation