Table 2 Results of overall and subgroup analyses for C1772T and G1790A polymorphisms
No. | T versus C | TT versus CC | TC versus CC | TT + TC versus CC | TT versus TC + CC | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P(Z) | OR | (95% CI) | P(z) | OR | (95% CI) | P(z) | OR | (95% CI) | P(z) | OR | (95% CI) | P(z) | ||
C1772T | ||||||||||||||||
Overall | 7 | 1.66 | 0.92–2.99 | 0.095 | 2.27 | 1.17–4.42 | 0.016 | 0.98 | 0.70–1.38 | 0.914 | 1.16 | 0.85–1.59 | 0.355 | 11.53 | 1.11–120.4 | 0.041 |
PCR-RFLP | 4 | 2.44 | 0.90–6.64 | 0.081 | 2.27 | 1.17–4.42 | 0.016 | 0.86 | 0.55–1.34 | 0.506 | 1.14 | 0.78–1.67 | 0.503 | 11.53 | 1.11–120.4 | 0.041 |
Sequencing | 3 | 1.20 | 0.70–2.03 | 0.506 | – | – | – | 1.20 | 0.69–2.09 | 0.514 | 1.20 | 0.69–2.09 | 0.514 | – | – | – |
Caucasian | 2 | 1.26 | 0.84–1.90 | 0.270 | 2.16 | 1.09–4.27 | 0.028 | 0.69 | 0.40–1.17 | 0.168 | 1.02 | 0.66–1.57 | 0.926 | 2.28 | 1.15–5.51 | 0.018 |
Asian | 4 | 1.37 | 0.88–2.13 | 0.159 | – | – | – | 1.30 | 0.82–2.07 | 0.269 | 1.34 | 0.85–2.12 | 0.213 | – | – | – |
HB | 3 | 1.31 | 0.90–1.90 | 0.162 | – | – | – | 0.92 | 0.57–1.48 | 0.736 | 1.13 | 0.73–1.74 | 0.582 | – | – | – |
PB | 4 | 2.87 | 0.82–10.0 | 0.099 | 2.01 | 0.75–5.41 | 0.168 | 1.05 | 0.64–1.73 | 0.843 | 1.20 | 0.76–1.89 | 0.442 | 22.82 | 0.28–1887.8 | 0.165 |
OC | 5 | 1.95 | 0.70–5.43 | 0.201 | 2.01 | 0.75–5.41 | 0.168 | 0.89 | 0.57–1.40 | 0.612 | 1.01 | 0.66–1.54 | 0.957 | 22.82 | 0.28–1887.8 | 0.165 |
G1790A | No. | A versus G | AA versus GG | AG versus GG | AA + AG versus GG | AA versus AG + GG | ||||||||||
OR | 95% CI | P(Z) | OR | (95% CI) | P(z) | OR | (95% CI) | P(z) | OR | (95% CI) | P(z) | OR | (95% CI) | P(z) | ||
Overall | 6 | 4.11 | 0.84–20.15 | 0.081 | 72.11 | 2.08–2502.4 | 0.018 | 1.94 | 0.83–4.55 | 0.128 | 3.57 | 0.97–13.14 | 0.055 | 58.05 | 1.70–1985.8 | 0.024 |
PCR-RFLP | 4 | 8.39 | 0.98–72.1 | 0.053 | 72.11 | 2.08–2502.4 | 0.018 | 2.81 | 0.91–8.72 | 0.074 | 7.00 | 1.18–41.68 | 0.032 | 58.05 | 1.70–1985.8 | 0.024 |
Sequencing | 2 | 1.01 | 0.50–2.03 | 0.975 | – | – | – | 1.01 | 0.50–2.06 | 0.975 | 1.01 | 0.50–2.06 | 0.975 | – | – | – |
Caucasian | 2 | 2.18 | 0.16–30.19 | 0.562 | – | – | – | 2.10 | 0.16–28.19 | 0.577 | 2.24 | 0.15–34.32 | 0.563 | – | – | – |
Asian | 3 | 1.59 | 0.67–3.78 | 0.294 | – | – | – | 1.57 | 0.69–3.58 | 0.283 | 1.59 | 0.67–3.76 | 0.290 | – | – | – |
HB | 2 | 0.86 | 0.43–1.72 | 0.667 | 0.85 | 0.42–1.73 | 0.660 | 0.85 | 0.42–1.73 | 0.660 | – | – | – | |||
PB | 4 | 9.43 | 1.20–73.9 | 0.033 | 72.11 | 2.08–2502.4 | 0.018 | 3.22 | 1.28–8.08 | 0.013 | 7.83 | 1.48–41.37 | 0.015 | 58.05 | 1.70–1985.8 | 0.024 |
OC | 4 | 9.66 | 1.31–71.15 | 0.026 | 72.11 | 2.08–2502.4 | 0.018 | 3.17 | 1.26–7.92 | 0.014 | 7.92 | 1.58–39.64 | 0.012 | 58.05 | 1.70–1985.8 | 0.024 |