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Table 5 Cox regression analysis of predictors of overall survival (OS) and disease progression-free survival (DFS)

From: Oncological outcomes of laparoscopic versus open gastrectomy after neoadjuvant chemotherapy for locally advanced gastric cancer: a retrospective multicenter study

Variables

OS

DFS

HR (95% CI)

P value

HR (95% CI)

P value

Age ≥ 70 years

1.16 (.995–1.25)

0.06

1.152 (1.025–1.29)

0.017

Male sex

0.584 (0.062–5.466)

0.63

0.736 (0.041–13.287)

0.83

Differentiation (moderate)

0.749 (0.007–78.71)

0.93

1.117 (0.001–17.07)

0.39

Differentiation (poor)

1.277 (0.018–4.249)

0.35

1.084 (0.002–2.86)

0.16

Tumor stage III

1.66 (0.23–1.92)

0.45

1.228 (0.34–1.2)

0.081

Radiological response (CR vs. SD/PD)

0.65 (025–1.69)

0.37

0.31 (0.06–2.8)

0.285

Laparoscopic gastrectomy

0.685 (0.112–4.201)

0.68

1.879 (0.092–38.47)

0.113

Total gastrectomy (distal vs. total)

1.299 (0.234–7.198)

0.76

3.9 (0.34–46.45)

0.274

Locoregional metastasis

1.081 (0.1–42.427)

0.43

4.842 (0.075–313.77)

0.45

Distant metastasis

4.53 (0.58–35.35)

0.15

23.479 (0.982–561.12)

0.051

R1 marginal resection

2.45 (0.29–20.29)

0.41

0.019 (0–2.4)

0.111

Complications (yes vs. no)–

0.168 (0.014–1.99)

0.16

2.470 (0.171–35.74)

0.51

Reintervention (yes vs. no)

35.56 (3.39–372.19)

0.003

2.934

0.997

Laparoscopic gastrectomy

1.016 (0.49–2.098)

0.96

0.858 (0.418–1.759)

0.67

  1. NOTE: CI confidence interval, CR complete response, HR hazard ratio, SD stable disease, PD progressive disease