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Table 1 The characteristics of included patients

From: Risk factors for radiation-induced lung injury in patients with advanced non-small cell lung cancer: implication for treatment strategies

Variables

RILI group (n = 45)

Non-RILI group (n = 81)

χ2/t

P

Male/female

31/14

48/33

1.029

0.112

Age (years)

61.01 ± 8.52

60.17 ± 9.33

4.381

0.065

BMI (kg/m2)

22.27 ± 4.15

22.09 ± 3.98

3.424

0.082

Diabetes

24 (53.33%)

20 (24.69%)

1.187

0.013

Hypertension

25 (55.56%)

44 (54.32%)

1.272

0.104

Hyperlipidemia

10 (22.22%)

16 (19.75%)

1.489

0.076

Smoke

31 (68.89%)

24 (29.63%)

1.233

0.014

COPD

18 (40%)

22 (27.16%)

1.504

0.046

Pathological type

 Squamous cell carcinoma

32 (71.11%)

58 (71.61%)

1.127

0.088

 Adenocarcinoma

13 (28.89%)

23 (28.39%)

Concurrent chemotherapy

39 (86.67%)

61 (75.31%)

1.231

0.039

KPS

84.43 ± 12.72

82.76 ± 11.23

1.107

0.092

Tumor staging

 IIIa

24 (53.33%)

44 (54.32%)

1.145

0.106

 IIIb

22 (48.89%)

37 (45.68%)

Cancer size (cm)

5.88 ± 3.26

5.65 ± 2.64

1.230

0.085

Radiotherapy dose (Gy)

63.75 ± 11.32

52.48 ± 10.66

9.277

0.001

V5

54.44 ± 11.68

53.26 ± 12.42

11.207

0.073

V10

32.76 ± 8.01

29.19 ± 9.54

8.021

0.081

V20

22.12 ± 5.37

21.35 ± 5.95

9.101

0.089

V30

12.31 ± 4.98

11.93 ± 4.17

4.116

0.105

MLD

949.59 ± 242.83

898.91 ± 282.44

77.174

0.059

GTV

169.05 ± 52.18

149.77 ± 61.72

18.101

0.091

PTV

472.34 ± 69.64

321.58 ± 79.84

53.374

0.011

  1. Note: The percentage of the lung volume that received more than a certain dose of the total lung volume was recorded as V5 (≤ 65%), V10 (≤ 20%.), V20 (≤ 25%), and V30 (≤ 20%) accordingly
  2. RILI radiation-induced lung injury, BMI body mass index, COPD chronic obstructive pulmonary disease, MLD mean lung dose, GTV gross target volume, PTV planning target volume