Table 8 Relationship between mutation of KRAS gene in exon E4 and clinical parameters
|  | Clinical parameters | No. | KRAS-E4 | Positive rate (%) | χ2 | p value | |
|---|---|---|---|---|---|---|---|
Wild type | Mutant type | ||||||
Age | ≤60 | 112 | 58 | 0 | 0 | 2.998 | 0.103 |
>60 | 109 | 69 | 0 | 0 | |||
Gender | Male | 114 | 70 | 0 | 0 | 1.493 | 0.276 |
Female | 107 | 57 | 0 | 0 | |||
Sample type | Tissue sample | 194 | 120 | 0 | 0 | 15.433 | <0.001 |
Whole blood sample | 22 | 4 | 0 | 0 | |||
Whole blood + tissue sample | 5 | 3 | 0 | 0 | |||
Pathological type | Squamous cell carcinoma | 15 | 9 | 0 | 0 | 0.047 | 0.997 |
Adenocarcinoma | 155 | 89 | 0 | 0 | |||
Adenosquamous carcinoma | 7 | 4 | 0 | 0 | |||
Staging | Stage IA | 22 | 13 | 0 | 0 | 8.274 | 0.309 |
Stage IB | 51 | 34 | 0 | 0 | |||
Stage IIA | 8 | 5 | 0 | 0 | |||
Stage IIB | 9 | 8 | 0 | 0 | |||
Stage IIIA | 23 | 13 | 0 | 0 | |||
Stage IIIB | 5 | 2 | 0 | 0 | |||
Stage IV | 33 | 16 | 0 | 0 | |||
Treatment | Surgery | 67 | 45 | 0 | 0 | 8.807 | 0.032 |
Chemotherapy | 37 | 17 | 0 | 0 | |||
Surgery + chemotherapy | 66 | 42 | 0 | 0 | |||