Table 2 Summary of nine selected genes and their roles as prognostic biomarkers in breast cancer.
Gene symbols | Gene names | Prognostic value in breast cancer with high expression | Cellular/biological roles |
|---|---|---|---|
CCNA2 | Cyclin A2 | Poor | Cell cycle regulator |
CENPN | Centromere protein N | Poor | Regulates kinetochore assembly |
DEPDC1 | DEP domain containing 1 | Poor | Transcription regulator |
TTK | TTK protein kinase | Poor | Regulates the spindle assembly checkpoint |
KIF2C | Kinesin family member 2C | Poor | Microtubule-dependent motor protein |
ABAT | 4-Aminobutyrate aminotransferase | Good | Metabolizes GABA |
LRIG1 | Leucine-rich repeats and immunoglobulin-like domains 1 | Good | Negatively regulates EGFR signaling |
PGR | Progesterone receptor | Good | Hormone receptor |
ESR1 | Estrogen Receptor 1 | Good | Hormone receptor |