Table 1 Subgroup analysis of the adverse events (AEs)

Any grade about neuropathy

0.60–2.10

Any grade anemia

0.59–1.52

Any grade decreased appetite

1.08–2.30

Any grade diarrhea

1.60–4.61

Any grade fatigue

0.92-1.71

Any grade febrile neutropenia

1.04–4.65

Any grade mucositis

2.33–6.34

Any grade nausea

1.16–3.24

Any grade neutropenia

0.86–1.52

Any grade thrombocytopenia

0.42–1.36

Any grade vomiting

1.26–2.09

Any grade white blood cell decrease

1.16–2.04

Grade 3 or higher about neuropathy

0.33–2.18

Grade 3 or higher anemia

0.73–2.03

Grade 3 or higher decreased appetite

0.56–3.57

Grade 3 or higher diarrhea

1.62–8.62

Grade 3 or higher elevated ALT

0.21–0.68

Grade 3 or higher fatigue

0.62–1.45

Grade 3 or higher febrile neutropenia

1.35–5.99

Grade 3 or higher mucositis

0.71–2.51

Grade 3 or higher nausea

1.26–10.30

Grade 3 or higher neutropenia

1.14–2.46

Grade 3 or higher thrombocytopenia

0.74–1.93

Grade 3 or higher vomiting

1.07–1.98

Grade 3 or higher white blood cell decrease

2.00–4.77

Death

0.20–1.23