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Table 2 Pathologic nodal findings from intraoperative analysis and final diagnosis of subjects with a false-negative frozen section of sentinel nodes (FNSN) and controls

From: False-negative frozen section of sentinel nodes in early breast cancer (cT1-2N0) patients

 

Control (n = 60)

FNSN (n = 20)

P value

Frozen section of lymph nodes

< 0.001

 Frozen section for relevant SNs and metastasis in nonrelevant SNs

0

4 (20%)

 False-negative results

0

16 (80%)

  Micrometastasis in SNs

  

7

   Metastasis in SNs and nonsentinel ALNs

  

1

   Metastasis only in SNs

  

6

  Macrometastasis in SNs

  

9

   Metastasis in SNs and nonsentinel ALNs

  

1

   Metastasis only in SNs

  

8

 True-negative results

60 (100%)

0

Lymphatic tumor emboli

10 (17%)

18 (90%)

< 0.001

Number of relevant SNs for frozen section

1 (0–9)

2 (1–4)

0.881

Number of hot spots in lymphoscintigraphy

1 (1–5)

1 (1–4)

0.570

Total number of SNs during the 1st operation

3 (1–13)

5.5 (1–17)

0.072

Lymph node invasion

< 0.001

 Negative

60 (100%)

0

 Positive

0

20 (100%)

Resected lymph nodes (including SLNB and ALND)

3 (1–13)

23 (9–39)

< 0.001

Positive lymph nodes (including SLNB and ALND)

0

2 (1–7)

< 0.001

Nodal stage

< 0.001

 N0

60 (100%)

0

 N1

0

17 (85%)

 N2

0

3 (15%)

AJCC TNM stage

< 0.001

 Stage IA

43 (72%)

0

 Stage IIA

17 (28%)

12 (60%)

 Stage IIB

0

5 (25%)

 Stage IIIA

0

3 (15%)