Fig. 1

CircLRP6 is highly expressed in PCa tissues and cells. A Heat maps showing the top differentially expressed circRNAs. B The expression of circLRP6 in normal tissues, low-grade PCa, and high-grade PCa tissues was detected using qRT-PCR. C CircLRP6 in PCa tissues or normal tissues was detected by ISH. D The expression of circLRP6 in PCa cells (PC3 and DU145) and normal RWPE-1 cells was determined with qRT-PCR. E The exonic information of circLRP6 was illustrated and the length of circLRP6 was 394 bp. F qRT-PCR analysis of circLRP6 expression in PC3 and DU145 cells treated with or without RNase R. *P < 0.05