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Table 2 Cox univariate and multivariate survival analyses to analyze the independent prognostic factors for colon cancer

From: The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer

Characteristics

HR

Univariate CI (95%)

P

HR

Multivariate CI (95%)

P

Sex

 (Male/female)

1.075

0.602, 0.337

0.086

0.774

0.419, 1.427

0.411

Age, years

  (≥ 60/< 60)

0.883

0.022, 1

0.883

0.87

0.473, 1.599

0.653

TNM stage

 T stage

2.584

1.601, 0.992

< 0.05*

1.779

1.019, 3.106

< 0.05*

 N stage

10.801

5.501, 2.801

< 0.01**

2.285

1.057, 4.938

< 0.05*

 M stage

13.214

7.309, 4.043

< 0.01**

2.984

1.594, 5.587

< 0.01**

Differentiation degree

 (high/medium/low)

3.141

1.924, 1.178

< 0.05*

0.801

0.442, 1.451

0.464

Tumor size

  (≥ 5 cm/< 5 cm)

1.295

0.762, 0.448

0.315

1.491

0.755, 2.944

0.25

CEA

  (Positive/negative)

0.996

0.578, 0.336

< 0.05*

0.778

0.421, 1.44

0.425

NCX1

  (Tumor/normal)

0.277

0.099, 0.036

< 0.01**

0.145

0.049, 0.43

< 0.01**

NCX2

  (Tumor/normal)

0.422

0.132, 0.041

< 0.01**

0.187

0.056, 0.628

< 0.01**

NCX3

  (Tumor/normal)

0.357

0.087, 0.021

< 0.01**

0.215

0.05, 0.936

< 0.05*

  1. Tumor/normal: the ratio of the NCX expression level in tumor tissues to that in normal tissues; *p < 0.05; **p < 0. 01