The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer

Table 1 Correlation between NCXs and the clinicopathological features of colon cancer

Clinicopathological feature	NCX1 expression				NCX2 expression				NCX3 expression
	Case	T/N < 1^a	T/N ≥ 1^b	P value	Case	T/N<1^a	T/N≥1^b	P value	Case	T/N < 1^a	T/N ≥ 1^b	P value
	n = 111	n = 74	n = 37	P value	n = 111	n = 81	n = 30	P value	n = 111	n = 84	n = 27	P value
Sex
Male	68	50	18	0.054	68	47	21	0.25	68	53	15	0.484
Female	43	24	19		43	34	9		43	31	12
Age, years
< 60	72	45	27	0.206	72	49	23	0.113	72	57	15	0.244
≥ 60	39	29	10		39	32	7		39	27	12
T stage^c
T2	8	5	3	0.948	8	6	2	0.738	8	6	2	0.571
T3	65	44	21		65	49	16		65	47	18
T4	38	25	13		38	26	12		38	31	7
N stage^c
N0	50	30	20	0.177	50	32	18	0.054	50	31	19	0.002**
N1	61	44	17		61	49	12		61	53	8
M stage^c
M0	92	56	36	0.004*	92	64	28	0.075	92	66	26	0.033*
M1	19	18	1		19	17	2		19	18	1
Differentiation
High	13	9	4	0.068	13	10	3	0.574	13	8	5	0.448
Medium	72	43	29		72	51	21		72	56	16
Low	26	22	4		26	20	6		26	20	6
Tumor size
≥ 5 cm	52	37	15	0.283	52	37	15	0.685	52	39	13	0.876
5 cm	59	35	22		59	44	15		59	45	14
CEA
Positive	58	40	18	0.591	58	44	14	0.473	58	44	14	0.962
Negative	53	34	19		53	37	16		53	40	13

^aThe expression level of NCX in tumor tissues is less than 1 compared with that in normal tissues
^bThe expression level of NCX in tumor tissues is greater than 1 compared with that in normal tissues
^cTNM stage; N1 lymph node metastasis, M1 distant metastasis; *p < 0.05, **p < 0.01

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