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Table 2 Univariate and multivariate Cox proportional-hazard regression analysis for overall survival in PDAC patients undergoing resection

From: Preoperative plasma D-dimer independently predicts survival in patients with pancreatic ductal adenocarcinoma undergoing radical resection

 

Patients (%)

Univariable analysis

Multivariable analysis

  

Hazard ratio

p

Hazard ratio

p

Age, ≥ 65

591 (43.75%)

1.23 (1.09-1.38)

0.001

1.13 (1.00-1.29)

0.057

Sex (male)

848 (62.77%)

1.05 (0.92-1.19)

0.468

  

Platelets, ≥ 200 × 109

561 (41.52%)

1.10 (0.98-1.25)

0.110

  

NLR, ≥ 3

470 (34.79%)

1.28 (1.12-1.45)

< 0.001

1.19 (1.05-1.36)

0.009

Albumin, < 40 g/L

742 (54.92%)

1.19 (1.05-1.34)

0.007

1.11 (0.98-1.26)

0.116

Obstructive jaundice

481 (35.60%)

1.16 (1.02-1.31)

0.025

0.94 (0.81-1.09)

0.424

D-dimer, ≥ 0.55 ng/mL

417 (30.87%)

1.47 (1.29-1.67)

< 0.001

1.33 (1.17-1.51)

< 0.001

CA19-9, ≥ 37 U/mL

1036 (76.68%)

1.40 (1.23-1.58)

< 0.001

1.25 (1.10-1.41)

0.001

Tumor location

     

 Head

857 (63.43%)

Ref.

   

 Body/tail

494 (36.57%)

0.97 (0.85-1.10)

0.639

  

Major vessel resection

191 (14.14%)

1.57 (1.33-1.86)

<0.001

1.08 (0.89-1.32)

0.419

Neural invasion

1155 (85.49%)

1.51 (1.26-1.81)

< 0.001

1.39 (1.15-1.67)

0.001

R1 resection, ≤ 1 mm

178 (13.18%)

1.51 (1.27-1.79)

< 0.001

1.39 (1.16-1.65)

< 0.001

T stage

     

 T1-T2

843 (62.40%)

Ref.

 

Ref.

 

 T3-T4

508 (37.60%)

1.57 (1.39-1.78)

< 0.001

1.54 (1.34-1.80)

< 0.001

N stage

     

 N0

705 (52.18%)

Ref.

 

Ref.

 

 N1-N2

646 (47.82%)

1.58 (1.40-1.79)

< 0.001

1.49 (1.31-1.69)

< 0.001

Differentiation

     

 Well-moderate

1113 (82.38%)

Ref.

 

Ref.

 

 Poor

238 (17.62%)

1.77 (1.52-2.06)

< 0.001

1.73 (1.48-2.02)

< 0.001

Adjuvant therapy

751 (55.59%)

0.61 (0.54-0.69)

< 0.001

0.61 (0.54-0.70)

< 0.001

  1. PDAC, pancreatic ductal adenocarcinoma; NLR, neutrophil lymphocyte ratio; CA19-9, serum carbohydrate antigen 19-9
  2. p value < 0.05 indicates statistical significance (in bold)