Table 3 HRs for RFS by subgroup
Subgroups | No. of studies | No. of patients | Random-effects model | Fixed-effects model | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | I2 | Ph | |||
Regions | ||||||||
 China | 9 | 397 | 0.63 (0.49–0.81) | 0.000 | 0.68 (0.57–0.81) | 0.000 | 41.8% | 0.089 |
 Other countries | 1 | 556 | 0.94 (0.78–1.13) | 0.513 | 0.94 (0.78–1.13) | 0.513 | 0% | 0 |
Study design | ||||||||
 Prospective | 2 | 570 | 0.53 (0.14–1.99) | 0.350 | 0.91 (0.75–1.09) | 0.292 | 82% | 0.018 |
 Retrospective | 8 | 383 | 0.67 (0.53–0.85) | 0.001 | 0.7 (0.58–0.83) | 0.000 | 32.3% | 0.170 |
Root of HRs | ||||||||
 Univariate | 4 | 799 | 0.91 (0.78–1.07) | 0.274 | 0.91 (0.78–1.07) | 0.274 | 52.8% | 0.060 |
 Multivariate | 6 | 154 | 0.51 (0.35–0.74) | 0.000 | 0.62 (0.5–0.76) | 0.000 | 0% | 0.84 |
Risk of factor (with vascular invasion or not) | ||||||||
 Yes | 6 | 240 | 0.51 (0.35–0.74) | 0.000 | 0.62 (0.5–0.76) | 0.000 | 52.4% | 0.062 |
 No | 4 | 713 | 0.92 (0.78–1.07) | 0.278 | 0.92 (0.78–1.07) | 0.278 | 0% | 0.855 |