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Fig. 2 | World Journal of Surgical Oncology

Fig. 2

From: MiR-194-5p enhances the sensitivity of nonsmall-cell lung cancer to doxorubicin through targeted inhibition of hypoxia-inducible factor-1

Fig. 2

The overexpression of miR-194-5p ameliorated DOX resistance in NSCLC cells induced by hypoxia. a The transcription of miR-194-5p in A549 miR-194-5p-overexpressing NSCLC cells was detected by RT-qPCR. b The CCK-8 method was used to detect the viability of miR-194-5p-overexpressing NSCLC cells and control NSCLC cells induced by hypoxia under different concentrations of DOX treatments. c TUNEL staining was used to detect the apoptosis rate of miR-194-5p-overexpressing NSCLC cells and control NSCLC cells (bar=25 μm). d The expression levels of HIF-1, BAX, Caspase-9, Caspase-3, PARP, and p-gp in miR-194-5p-overexpressing NSCLC cells and control NSCLC cells induced by hypoxia were detected by western blot. Data are presented as the mean ± SD. *P <0.05; ***P < 0.001

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