Fig. 2

CircASXL1 silencing suppressed CRC progression. A CircASXL1 silencing reduced circASXL1 expression in SW480 and SW620 cells. B CircASXL1 knockdown repressed colony-forming ability of SW480 and SW620 cells. C, D CircASXL1 silencing induced cell arrest in G0/G1 phase and cell apoptosis in SW480 and SW620 cells. E, F CircASXL1 silencing downregulated Bcl-2 protein expression, and upregulated Bax protein expression. G–I CircASXL1 absence inhibited the migration and invasion of SW480 and SW620 cells. Significant differences were compared with two-tailed Student’s t tests. *P < 0.05