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Fig. 9 | World Journal of Surgical Oncology

Fig. 9

From: Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia

Fig. 9

MUC19 overexpression partly reversed the inhibitory effects of miR-1287-5p mimic on BC cell viability, migration, and invasion. a–h The MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment were co-transfected with miR-NC, miR-1287-5p, miR-1287-5p + vector, or miR-1287-5p + MUC19, respectively. a, b Cell activity was assessed by MTT assay in transfected MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. c, d The protein levels of cyclin D1 and PCNA in transfected MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment were detected by western blot. e–h Transwell assay was used to investigate the migration and invasion abilities of transfected MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. *P < 0.05

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