Fig. 8

MUC19 overexpression partly reversed the inhibitory effects of miR-1287-5p mimic on BC cells glycolysis. a–d The mRNA and protein levels of MUC19 in BC cells co-transfected with miR-NC, miR-1287-5p, miR-1287-5p + vector, or miR-1287-5p + MUC19 were evaluated by qRT-PCR in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. e, f Glucose consumption in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment was assessed. g, h Lactic acid production in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment was detected. i, j Western blot assay was used to detect the protein level of HK2 in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. *P < 0.05