Table 6 Diagnostic efficacy of four tumor markers in HCC
Index(es) | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
AFP | 0.866 (0.783–0.950) | 78.7 | 92.5 | 78.7 | 92.5 |
Hsp90α | 0.934 (0.882–0.986) | 95.7 | 75.0 | 95.7 | 75.0 |
CEA | 0.694 (0.584–0.804) | 51.1 | 81.5 | 27.7 | 100 |
CA199 | 0.700 (0.592–0.808) | 48.9 | 81.5 | 48.9 | 85.0 |
AFP + Hsp90α | 0.990 (0.976–1.000) | 95.7 | 97.5 | 74.5 | 70.0 |
AFP + CA199 | 0.896 (0.829–0.964) | 74.5 | 100 | 40.4 | 72.5 |
AFP + CEA | 0.903 (0.933–0.972) | 78.7 | 97.5 | 23.4 | 75.0 |
CEA + Hsp90α | 0.932 (0.879–0.984) | 70.2 | 100 | 27.7 | 60.0 |
CA199 + Hsp90α | 0.936 (0.885–0.987) | 91.5 | 81.5 | 48.9 | 62.5 |
CEA + CA199 | 0.736 (0.633–0.839) | 42.6 | 95.0 | 25.5 | 70.0 |
AFP + CEA + CA199 | 0.900 (0.833–0.967) | 76.6 | 100 | 21.3 | 62.5 |
AFP + CEA + Hsp90α | 0.990 (0.976–1.000) | 95.7 | 97.5 | 23.4 | 57.5 |
AFP + CA199 + Hsp90α | 0.991 (0.980–1.000) | 91.5 | 100 | 40.4 | 57.5 |
CEA + CA199 + Hsp90α | 0.938 (0.888–0.989) | 91.5 | 85.0 | 25.5 | 55.0 |
Four indexes combined | 0.993 (0.982–1.000) | 97.9 | 92.5 | 21.3 | 50.0 |