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Table 6 Diagnostic efficacy of four tumor markers in HCC

From: Plasma heat shock protein 90alpha as a biomarker for the diagnosis of liver cancer: in patients with different clinicopathologic characteristics

Index(es) AUC (95% CI) Sensitivity (%) Specificity (%) PPV (%) NPV (%)
AFP 0.866 (0.783–0.950) 78.7 92.5 78.7 92.5
Hsp90α 0.934 (0.882–0.986) 95.7 75.0 95.7 75.0
CEA 0.694 (0.584–0.804) 51.1 81.5 27.7 100
CA199 0.700 (0.592–0.808) 48.9 81.5 48.9 85.0
AFP + Hsp90α 0.990 (0.976–1.000) 95.7 97.5 74.5 70.0
AFP + CA199 0.896 (0.829–0.964) 74.5 100 40.4 72.5
AFP + CEA 0.903 (0.933–0.972) 78.7 97.5 23.4 75.0
CEA + Hsp90α 0.932 (0.879–0.984) 70.2 100 27.7 60.0
CA199 + Hsp90α 0.936 (0.885–0.987) 91.5 81.5 48.9 62.5
CEA + CA199 0.736 (0.633–0.839) 42.6 95.0 25.5 70.0
AFP + CEA + CA199 0.900 (0.833–0.967) 76.6 100 21.3 62.5
AFP + CEA + Hsp90α 0.990 (0.976–1.000) 95.7 97.5 23.4 57.5
AFP + CA199 + Hsp90α 0.991 (0.980–1.000) 91.5 100 40.4 57.5
CEA + CA199 + Hsp90α 0.938 (0.888–0.989) 91.5 85.0 25.5 55.0
Four indexes combined 0.993 (0.982–1.000) 97.9 92.5 21.3 50.0