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Table 4 Results of univariate and multivariate Cox regression analyses

From: The assessment of risk factors for long-term survival outcome in ypN0 patients with rectal cancer after neoadjuvant therapy and radical anterior resection

  

Univariate

Multivariate

  

HR

CI 2.5%

CI 97.5%

p

HR

CI 2.5%

CI 97.5%

p

DFS

CCI ≤ 3

Ref.

       
 

CCI > 3

5.438

2.043

14.48

< 0.001

5.779

2.153

15.51

< 0.001

 

Female

Ref.

       
 

Male

2.19

0.9255

5.184

0.0744

    
 

PRETR ST II

Ref.

       
 

PRETR ST III

0.6896

0.3156

1.506

0.3512

    
 

Dist av

1–5 cm

Ref.

       
 

6–10 cm

0.6141

0.2494

1.512

0.2889

    
 

11–15 cm

1.269

0.4858

3.313

0.6269

    
 

ypT0

Ref.

       
 

ypT1–2

1.888

0.2451

14.55

0.5417

    
 

ypT3

3.031

0.3978

23.1

0.2845

    
 

LNY 1–7

Ref.

       
 

LNY 8–12

2.106

0.5791

7.66

0.2581

    
 

LNY > 12

3.106

0.8916

10.82

0.0751

    
 

No AL

Ref.

       
 

AL

3.066

1.403

6.702

0.005

    
 

No AL

Ref.

       
 

Early AL

2.001

0.6725

5.953

0.2125

1.96

0.6587

5.831

0.2265

 

Late AL

4.753

1.87

12.08

0.0011

5.051

1.974

12.93

< 0.001

 

No adj CT

Ref.

       
 

Adj CT

0.695

0.1632

2.959

0.6225

    

DSS

CCI ≤ 3

Ref.

       
 

CCI > 3

5.39

1.754

16.56

0.0033

7.252

2.249

23.39

< 0.001

 

Female

Ref.

       
 

Male

1.543

0.54

4.41

0.418

    
 

PRETR ST II

Ref.

       
 

PRETR ST III

0.643

0.2443

1.692

0.3711

    
 

Dist av

1–5 cm

Ref.

       
 

6–10 cm

0.5699

0.1834

1.771

0.3309

    
 

11–15 cm

1.458

0.4378

4.855

0.5392

    
 

ypT0

Ref.

       
 

ypT1–2

0.7613

0.0883

6.565

0.804

    
 

ypT3

2.153

0.2754

16.83

0.4648

    
 

LNY 1–7

Ref.

       
 

LNY 8−12

1.605

0.3207

8.033

0.5648

    
 

LNY > 12

2.267

0.4854

10.59

0.2979

    
 

No AL

Ref.

       
 

AL

3.218

1.222

8.476

0.018

    
 

No AL

Ref.

       
 

Early AL

1.245

0.2705

5.73

0.7785

1.543

0.3303

7.21

0.5812

 

Late AL

8.519

2.825

25.69

< 0.001

10.84

3.435

34.18

< 0.001

 

No adj CT

Ref.

       
 

Adj CT

0.4898

0.0642

3.735

0.4911

    

OS

CCI ≤ 3

Ref.

       
 

CCI > 3

3.494

1.553

7.859

0.0025

3.899

1.718

8.85

0.0011

 

Female

Ref.

       
 

Male

0.984

0.5321

1.82

0.9591

    
 

PRETR ST II

Ref.

       
 

PRETR ST III

0.6993

0.3791

1.29

0.2522

    
 

Dist av 1–5 cm

Ref.

       
 

6–10 cm

0.5456

0.281

1.06

0.0736

    
 

11–15 cm

0.7257

0.3136

1.679

0.4538

    
 

ypT0

Ref.

       
 

ypT1–2

1.258

0.2893

5.466

0.7598

    
 

ypT3

2.332

0.5488

9.905

0.2514

    
 

LNY 1–7

Ref.

       
 

LNY 8–12

0.8853

0.3847

2.037

0.7746

    
 

LNY > 12

1.064

0.4784

2.365

0.8798

    
 

No AL

Ref.

       
 

AL

2.103

1.109

3.987

0.0227

    
 

No AL

Ref.

       
 

Early AL

1.292

0.5347

3.123

0.5691

1.415

0.5835

3.431

0.4425

 

Late AL

3.943

1.792

8.677

< 0.001

4.298

1.939

9.526

< 0.001

 

No adj CT

Ref.

       
 

Adj CT

0.8261

0.2933

2.327

0.7177

    
  1. Bold values indicate statistical significance
  2. DFS disease-free survival, DSS disease-specific survival, OS overall survival, HR hazard ratio, CI confidence interval, CCI Charlson comorbidity index, Dist av distance from the anal verge, PRETR ST pretreatment clinical stage, RT radiotherapy, LNY lymph node yield, AL anastomotic leakage, Adj CT adjuvant chemotherapy