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Table 4 Univariate and Multivariable Cox Regression Analysis for Overall Survival

From: Neoadjuvant chemotherapy followed by hyperthermic intraperitoneal chemotherapy for patients with colorectal peritoneal metastasis: a retrospective study of its safety and efficacy

Variable

Overall survival

Univariate analysis

Multivariate analysis

HR (95%CI)

P

HR (95%CI)

P

Gender: female/male

1.13 (0.53–2.43)

0.753

  

Age at operation (≥ 65 years/< 65 years)

2.12 (0.98–4.60)

0.056

  

Preoperative chemotherapy (yes/no)

0.36 (0.13–0.92)

0.033

0.55 (0.22–1.39)

0.204

T stage (T4/T3)

1.61 (0.73–3.54)

0.235

  

N stage

    

 N0

Reference

Reference

  

 N1

1.29 (0.57–2.94)

0.545

  

 N2

2.26 (0.71–7.16)

0.167

  

Site of original (rectum/colon)

1.48 (0.63–3.51)

0.373

  

Histology (mucinous/adenocarcinoma)

2.05 (0.96–4.40)

0.065

  

Preoperative CEA level (≥ 5 ng/ml/< 5 ng/ml)

1.68 (0.78–3.58)

0.183

  

Liver metastases (yes/no)

1.24 (0.50–3.08)

0.648

  

HIPEC regimen (lobaplatin/non-lobaplatin)

1.38 (0.62–3.05)

0.427

  

Presence of ascites (yes/no)

1.20 (0.55–2.60)

0.650

  

PCI score (≥ 12/< 12)

2.98 (1.41–6.32)

0.004

1.49 (0.61–3.66)

0.381

CC score (2–3/0–1)

4.20 (1.89–9.36)

< 0.001

2.99 (1.14–7.84)

0.026

Grade 3–4 postoperative complication (yes/no)

1.62 (0.74–3.57)

0.229

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