|
Subgroups
|
No. of studies
|
Pooled HR (95% CI)
|
Heterogeneity
|
|---|
|
I2 (%)
|
p value
|
|---|
|
Region
|
|
Eastern
|
8
|
1.793 (1.314–2.447)
|
68.69
|
0.002
|
|
Western
|
1
|
1.600 (0.591–4.333)
|
0
|
1
|
|
Sample sizes
|
|
< 200
|
5
|
2.646 (1.599–4.378)
|
61.822
|
0.033
|
|
≥ 200
|
4
|
1.289 (1.075–1.546)
|
0
|
0.584
|
|
Stage
|
|
I–III
|
5
|
2.115 (1.297–3.449)
|
76.339
|
0.002
|
|
Include IV
|
4
|
1.477 (1.044–2.089)
|
40.865
|
0.167
|
|
Treatment
|
|
Surgery
|
5
|
1.554 (1.077–2.244)
|
68.94
|
0.012
|
|
Chemotherapy
|
2
|
4.448 (2.114–9.360)
|
0
|
0.982
|
|
Liver resection
|
2
|
1.672 (1.212–2.308)
|
0
|
0.84
|
|
Cut-off value
|
|
≥ 0.1
|
4
|
2.269 (1.215–4.240)
|
55.379
|
0.081
|
|
< 0.1
|
5
|
1.613 (1.129–2.304)
|
71.106
|
0.008
|
|
Analysis method
|
|
MV
|
7
|
1.610 (2.214–2.135)
|
61.628
|
0.016
|
|
UV
|
2
|
2.769 (1.024–7.490)
|
57.907
|
0.123
|
- CI confidence interval, HR hazard ratio, MV multivariate, UV univariate
