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Table 3 Subgroup analysis of disease-free survival/progression-free survival

From: Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis

Subgroups

No. of studies

Pooled HR (95% CI)

Heterogeneity

I2 (%)

p value

Region

 Eastern

8

1.793 (1.314–2.447)

68.69

0.002

 Western

1

1.600 (0.591–4.333)

0

1

Sample sizes

 < 200

5

2.646 (1.599–4.378)

61.822

0.033

 ≥ 200

4

1.289 (1.075–1.546)

0

0.584

Stage

 I–III

5

2.115 (1.297–3.449)

76.339

0.002

 Include IV

4

1.477 (1.044–2.089)

40.865

0.167

Treatment

 Surgery

5

1.554 (1.077–2.244)

68.94

0.012

 Chemotherapy

2

4.448 (2.114–9.360)

0

0.982

 Liver resection

2

1.672 (1.212–2.308)

0

0.84

Cut-off value

 ≥ 0.1

4

2.269 (1.215–4.240)

55.379

0.081

 < 0.1

5

1.613 (1.129–2.304)

71.106

0.008

Analysis method

 MV

7

1.610 (2.214–2.135)

61.628

0.016

 UV

2

2.769 (1.024–7.490)

57.907

0.123

  1. CI confidence interval, HR hazard ratio, MV multivariate, UV univariate