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Table 3 Subgroup analysis of disease-free survival/progression-free survival

From: Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis

Subgroups No. of studies Pooled HR (95% CI) Heterogeneity
I2 (%) p value
Region
 Eastern 8 1.793 (1.314–2.447) 68.69 0.002
 Western 1 1.600 (0.591–4.333) 0 1
Sample sizes
 < 200 5 2.646 (1.599–4.378) 61.822 0.033
 ≥ 200 4 1.289 (1.075–1.546) 0 0.584
Stage
 I–III 5 2.115 (1.297–3.449) 76.339 0.002
 Include IV 4 1.477 (1.044–2.089) 40.865 0.167
Treatment
 Surgery 5 1.554 (1.077–2.244) 68.94 0.012
 Chemotherapy 2 4.448 (2.114–9.360) 0 0.982
 Liver resection 2 1.672 (1.212–2.308) 0 0.84
Cut-off value
 ≥ 0.1 4 2.269 (1.215–4.240) 55.379 0.081
 < 0.1 5 1.613 (1.129–2.304) 71.106 0.008
Analysis method
 MV 7 1.610 (2.214–2.135) 61.628 0.016
 UV 2 2.769 (1.024–7.490) 57.907 0.123
  1. CI confidence interval, HR hazard ratio, MV multivariate, UV univariate