Table 1 Summary of the retrieved studies investigating pre-treatment C-reactive protein to albumin ratio on survival in colorectal cancer patients

Ishizuka

2016

Japan

CRC

627

400:227

NA

0–IV

Surgery

0.038

OS

2.596

1.603–4.204

NA

MV

8

Shibutani

2016

Japan

CRC

99

57:42

63 (27–86)

IV

Chemotherapy

0.183

OS

1.866

1.057–3.295

2.6–73.2

MV

8

Shibutani

2016

Japan

CRC

705

411:294

68 (26-90)

I–III

Surgery

0.0278

DFS

CSS

1.503 1.672

1.054–2.143

1.012–2.764

NA

MV

8

Solaini

2016

UK

CRLM

194

125:69

66 (59-73)

IV

Liver resection

0.133

OS

2.04

1.26–3.3

NA

UV

7

Haruki

2017

Japan

CRLM

106

76:30

64.5 (39-87)

IV

Liver resection

0.04

OS

DFS

2.559 1.731

1.420–4.613

1.087–2.758

NA

MV

8

Ide

2017

Japan

Rectum

115

82:33

64 (33–83)

I–III

Surgery

0.049

OS

DFS

5.09

4.98

2.31–11.58

2.34–11.14

65 (2–189)

MV

8

Dolan

2018

UK

Colon

801

430:371

NA

I–III

Surgery

0.22

OS

CSS

1.84 1.76

1.49–2.26

1.31–2.35

NA

MV

7

Climent

2019

Ireland

CRC

566

260:306

69.9 ± 12.3

I–III

Surgery

0.46

OS

DFS

1.84 1.73

1.1–3.1

0.8–3.3

NA

UV

6

Shibutani

2019

Japan

CRC

40

25:15

NA

IV

Chemotherapy

0.122

OS

PFS

6.478 4.525

1.374–30.537

0.826–24.794

NA

MV

8

Sakamoto

2020

Japan

CRLM

184

121:63

63.1 (25-94)

IV

Liver resection

0.093

OS

PFS

2.82 1.62

1.63–4.72

1.02–2.49

NA

MV

8

Son

2020

Korea

CRC

789

486:283

NA

I–III

Surgery

0.14

OS

1.97

1.47–2.64

91 (67–115)

UV

7

Suzuki

2020

Japan

Colon

1303

689:614

65 (26-93)

II–III

Surgery

0.02558

OS

DFS

1.8

1.28

1.24–2.68

0.99–1.66

60.2 (3–106)

MV

8

Ni

2016

china

CRC

148

97:51

NA

IV

Chemotherapy

0.6712

OS

2.243

1.450–3.470

NA

MV

8

Zhou

2018

china

CRC

516

331:185

NA

I–IV

Surgery

0.07/0.08

OS

DFS

1.59 1.05

0.86–2.91

0.71–1.56

21.72 (2.11–118.72)

MV

8

Tominaga

2016

Japan

Colon

136

79:57

NA

III

Chemotherapy

0.1

DFS

4.43

1.94–10.15

NA

UV

7