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Table 3 Complications of the included studies

From: Meta-analysis of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced rectal cancer

Study Treatment Patients Related complications
Matsumoto, 2015 [17] NAC 15 Grade 3–4 adverse events: 2 neutropenia and 1 diarrhea
NACRT 109 NA
Okuyama, 2018 [18] NAC 27 Grade 3–4 adverse events: no;
Frequent toxic events:grade 1 neutropenia
NACRT 28 Grade 3–4 adverse events: no;
Frequent toxic events: grade 1 diarrhea
Deng, 2019 [29] NAC 152 Grade 3/4 toxicities: leukopenia 9; neutropenia 15; nausea/vomiting 4; diarrhea 12
NACRT 292 Grade 3/4 toxicities: leukopenia 48; neutropenia 40; nausea/vomiting 13; diarrhea 35; radiation dermatitis 54; radiation proctitis 35;
  1. Note: NAC neoadjuvant chemotherapy without radiation, NACRT neoadjuvant chemoradiation therap, NA not available