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Table 3 Complications of the included studies

From: Meta-analysis of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced rectal cancer

Study

Treatment

Patients

Related complications

Matsumoto, 2015 [17]

NAC

15

Grade 3–4 adverse events: 2 neutropenia and 1 diarrhea

NACRT

109

NA

Okuyama, 2018 [18]

NAC

27

Grade 3–4 adverse events: no;

Frequent toxic events:grade 1 neutropenia

NACRT

28

Grade 3–4 adverse events: no;

Frequent toxic events: grade 1 diarrhea

Deng, 2019 [29]

NAC

152

Grade 3/4 toxicities: leukopenia 9; neutropenia 15; nausea/vomiting 4; diarrhea 12

NACRT

292

Grade 3/4 toxicities: leukopenia 48; neutropenia 40; nausea/vomiting 13; diarrhea 35; radiation dermatitis 54; radiation proctitis 35;

  1. Note: NAC neoadjuvant chemotherapy without radiation, NACRT neoadjuvant chemoradiation therap, NA not available