Fig. 9
From: Identification of a ferroptosis-related gene signature predictive model in colon cancer
The pattern diagram of ferroptosis-related genes in colon cancer. Erastin deprives cellular cysteine, leading to GSH deletion and GPX4 inactivation. GSH is inhibited by cysteinyl-tRNA synthetase (CARS), leading to GPX4 inactivation. TPAP2C promotes the expression of GPX4 inactivation that leads to the generation of reactive oxygen species (ROS) and accumulation of lipid peroxides and final ferroptosis. NOX4, CKDN2A, and the decrease of GLUT3 and DRD4 result in accumulation of ROS, leading to ferroptosis. The mechanism of how WIPI1 regulates ferroptosis is unclear