Characteristics | Studies | Participants (ER-LG/LG-only) | Mean difference (95% CI) | Heterogeneity |
---|---|---|---|---|
Baseline information | ||||
Age, year | 7 | 540/2766 | 4.08 [2.10, 6.07]; P<0.0001 | I2=71%; P=0.002 |
Male | 9 | 595/3016 | 1.51 [1.23, 1.85]; P<0.0001 | I2=39%; P=0.11 |
BMI, kg/m2 | 8 | 570/2938 | 0.08 [−0.21, 0.37]; P=0.58 | I2=0%; P=0.50 |
Tumor size, cm | 3 | 237/1606 | −0.77 [−1.00, −0.55]; P<0.00001 | I2=0%; P=0.63 |
ASA 1 | 3 | 106/153 | 1.00 [0.56, 1.77]; P=1.00 | I2=0%; P=0.81 |
ASA 2 | 3 | 106/153 | 1.03 [0.59,1.80]; P=0.92 | I2=0%; P=0.87 |
T1-T2 | 7 | 463/2510 | 2.42 [1.09, 5.34]; P=0.03 | I2=40%; P=0.13 |
T3-T4 | 7 | 463/2510 | 0.41 [0.19, 0.91]; P=0.03 | I2=40%; P=0.13 |
Pathological undifferentiated | 3 | 89/231 | 0.28 [0.07, 1.18]; P=0.08 | I2=70%; P=0.04 |
Pathological differentiated | 3 | 89/231 | 3.52 [0.85, 14.60]; P=0.08 | I2=70%; P=0.04 |
Comorbidity | 3 | 166/718 | 1.76 [1.23, 2.51]; P=0.002 | I2=21%; P=0.28 |
Surgical methods and reconstruction methods | ||||
Total gastrectomy | 4 | 275/1644 | 0.94 [0.59, 1.49]; P=0.79 | I2=0%; P=0.86 |
Subtotal gastrectomy | 4 | 275/1644 | 1.07 [0.70, 1.65]; P=0.75 | I2=0%; P=0.86 |
B-I or B-II | 4 | 290/1200 | 1.09 [0.61, 1.93]; P=0.77 | I2=62%; P=0.05 |
Roux-en-Y | 4 | 290/1200 | 0.93 [0.64, 1.34]; P=0.69 | I2=21%; P=0.28 |
Short-term outcomes | ||||
Intraoperative blood loss | 6 | 442/2489 | −1.42 [−22.00, 19.16]; P=0.89 | I2=77%; P=0.0005 |
Time to first oral feeding | 3 | 55/118 | −0.02 [−0.34, 0.31]; P=0.93 | I2=0%; P=0.45 |
Retrieved lymph nodes | 6 | 350/1412 | −2.62 [−5.32, 0.07]; P=0.06 | I2=72%; P=0.003 |
Metastatic lymph nodes | 7 | 459/2338 | 0.66 [0.43, 1.00]; P=0.05 | I2=0%; P=0.50 |
Postoperative hospital stay | 6 | 442/2489 | 0.54 [−0.27, 1.35]; P=0.19 | I2=0%; P=1.00 |
Conversion to open surgery | 3 | 357/2199 | 0.73 [0.29, 1.86]; P=0.51 | I2=0%; P=0.73 |
Postoperative complications | ||||
Grade ≥ II | 4 | 305/1658 | 1.11 [0.71, 1.73]; P=0.64 | I2=0%; P=0.69 |
Grade ≥ III b | 3 | 284/1637 | 1.47 [0.49, 4.43]; P=0.49 | I2=0%; P=0.50 |
Anastomotic leakage | 7 | 544/2832 | 1.20 [0.55, 2.65]; P=0.65 | I2=0%; P=0.79 |
Anastomotic stenosis | 4 | 369/2049 | 1.34 [0.54, 3.33]; P=0.53 | I2=0%; P=0.66 |
Intestinal obstruction | 7 | 522/2807 | 1.70 [0.93, 3.13]; P=0.08 | I2=10%; P=0.36 |
Abdominal infection | 5 | 420/2315 | 1.59 [0.71, 3.56]; P=0.26 | I2=0%; P=0.65 |
Gastric stasis | 5 | 472/2651 | 0.71 [0.31, 1.65]; P=0.43 | I2=0%; P=0.93 |
Wound infection | 6 | 519/2745 | 1.68 [0.84, 3.35]; P=0.14 | I2=0%; P=0.90 |
Pancreatic leakage | 5 | 328/1238 | 1.25 [0.53, 2.94]; P=0.62 | I2=9%; P=0.36 |
Post-operative bleeding | 4 | 464/2627 | 0.69 [0.24, 2.01]; P=0.50 | I2=0%; P=1.00 |
Short-term death | 3 | 353/2027 | 2.65 [0.77, 9.09]; P=0.12 | I2=0%; P=0.88 |