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Table 3 Competing risk analysis of 5-year mortality

From: Survival analysis of extramammary Paget’s disease (EMPD) in a tertiary hospital in Taiwan

Variate

Mortality rate

Sub-HR

95% CI

p-value

Gender

 Female

16.67%

Reference

Reference

Reference

 Male

39.53%

2.737

0.632–11.859

0.1784

Age

 Age less than 75 years old

24.00%

Reference

Reference

Reference

 Age= 75 years old or more

43.33%

2.127

0.808–5.600

0.1265

Lesion site

 Genital region or others

26.32%

Reference

Reference

Reference

 Perianal or perineal region

52.94%

2.338

0.948–5.765

0.0651

Size of lesion

 Lesion = 2 cm or less

26.32%

Reference

Reference

Reference

 Lesion lager than 2 cm

38.89%

1.624

0.584–4.514

0.3527

Invasion of dermis

 No dermal invasion

28.95%

Reference

Reference

Reference

 Micro-invasion

20.00%

0.695

0.154–3.137

0.6362

 Deep dermal invasion

85.71%

5.167

1.876–14.230

0.0015

Metastasis status

 Without metastasis

27.08%

Reference

Reference

Reference

 Metastatic diseases

85.71%

4.513

1.683–12.103

0.0028

Recurrence (N=51)

 No recurrence

27.91%

Reference

Reference

Reference

 With recurrence

62.50%

2.587

0.907–7.382

0.0756

Concurrent malignancy

 No concurrent malignancy

29.41%

Reference

Reference

Reference

 Adnexal carcinoma

33.33%

1.180

0.151–9.225

0.8744

 Internal malignancy

44.44%

1.595

0.629–4.044

0.3249

Types of treatment

 With surgical excision

31.91%

Reference

Reference

Reference

 Without surgical excision

50.00%

1.642

0.544–4.950

0.3787

Margin status (N=47)

 Margin not free

33.33%

Reference

Reference

Reference

 Margin free

31.03%

0.911

0.324–2.561

0.8596

Intraepithelial lesion (N= 31)

 Margin not free

37.50%

Reference

Reference

Reference

 Margin free

21.74%

0.528

0.126–2.211

0.3822

  1. Abbreviation: CI confidence interval, Sub-HR sub-hazard ratio