Table 1 Demographics and clinical data of 55 study patients with EMPD
From: Survival analysis of extramammary Paget’s disease (EMPD) in a tertiary hospital in Taiwan
Variable | Patients |
|---|---|
Patient characteristics | |
Gender (male) | |
Male | 43 (78.18%) |
Female | 12 (21.82%) |
Age (year) (mean= 72.67, range 44–89) | |
Age < 65 years old | 14 (25.45%) |
Age= 65–74 years old | 11 (20.00%) |
Age = 75 years old or more | 30 (54.55%) |
Anatomic site of lesion | |
Scrotum or penis | 22 (40.00%) |
Vulva or labia | 7 (12.73%) |
Perianal or perineal region | 17 (30.91%) |
Trunk or others | 9 (16.36% ) |
Types of treatment | |
Surgical excision only | 39 (70.91%) |
Surgical excision with adjuvant therapy | 8 (14.55%) |
Radiotherapy or chemotherapy only | 4 (7.27%) |
Refused any treatment | 4 (7.27%) |
Recurrence (N=51) | 8 (15.69%) |
Concurrent malignancy | (N=21, 38.18%) |
Adnexal carcinoma | 3 (5.46%) |
Internal malignancy | 18 (32.73%) |
Underlying diseases | |
Without any underlying diseases | 14 (25.45%) |
Cardiovascular diseases | 30 (54.55%) |
Respiratory diseases | 5 (9.09%) |
Metabolic or endocrine diseases | 15 (27.27%) |
Nephrology disease | 3 (5.45%) |
Gastrointestinal disease | 8 (14.55%) |
Pathological parameter | |
Size of lesion (length of maximal diameter) | |
2 cm or less than 2 cm | 19 (34.55%) |
More than 2 cm | 36 (65.45%) |
Depth of invasion | |
Intraepithelial | 38 (69.09%) |
Micro-invasion of upper dermis | 10 (18.18%) |
Deep invasion | 7 (12.73%) |
Immunohistochemical staining (N=36) | |
Positive of CK7 | 33 (91.67%) |
Positive of CK20 | 8 (22.22%) |
Positive of GCDFP-15 | 5 (13.89%) |
Positive of Cdx2 | 8 (22.22%) |
Metastasis status (N=7, 12.72%) | |
Unilateral lymph node metastasis | 3 (5.45%) |
Bilateral lymph node metastasis | 1 (1.82%) |
Distant metastasis | 3 (5.45%) |