Table 3 Univariate and multivariate analysis of prognostic factors for stage II patients with <12 ELNs. We analyzed the prognostic factors for those patients. As listed in Table 3, univariate analysis showed that LVI, pT-stage, degree of differentiation, serum CEA and CA19-9 levels, perineural invasion, tumor budding, and KRAS status were significant prognostic factors for those patients

Sex

0.675

 Female

53

67.9

 Male

55

69.1

Age (years)

0.255

 ≤65

54

64.8

 >65

54

72.2

Tumor site

0.384

 Colon

57

63.2

 Rectum

51

68.6

Tumor size (cm)

0.078

 ≤4

60

61.7

 >4

48

77.1

Lymphovascular invasion

2.313 (1.897–4.562)

0.016

2.313 (1.897–4.562)

0.033

 Positive

48

60.4

 Negative

60

75.0

T-stage

2.358 (1.767–3.897)

<0.001

2.358 (1.767–3.897)

0.001

 T3

59

81.4

 T4

49

53.1

Differentiation degree

1.879 (1.223-4.563)

0.002

1.879 (1.223-4.563)

0.044

 Well

53

77.4

 Moderate

53

62.3

 Poor

2

0

CEA

3.011 (1.997–4.967)

<0.001

3.011 (1.997–4.967)

<0.001

 ≤5ng/ml

61

78.7

 >5ng/ml

47

55.3

CA19-9

1.935 (1.156–3.768)

0.001

1.935 (1.156–3.768)

0.015

 ≤37U/ml

69

75.4

 >37U/ml

39

56.4

KRAS status

2.430 (1.238–4.770)

0.010

2.277 (1.115–4.653)

0.013

 Wild type

68

76.5

 Mutant type

40

55.0

PNI

2.848 (1.386–5.852)

0.004

2.837 (1.090–5.385)

0.003

 Positive

19

42.1

 Negative

89

74.2

2.480 (1.251–4.916)