Table 2 Univariate and multivariate analysis of variant parameters in CRC patients by Cox regression analysis
Variables | Test cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
Multivariate | Multivariate | |||||
Univariate p value | HR (95%CI) | p value | Univariate p value | HR (95%CI) | p value | |
Age: ≤60 vs >60 | 0.793 | NA | NA | 0.095 | NA | NA |
Sex: male vs female | 0.342 | NA | NA | 0.573 | NA | NA |
Location: colon vs rectum | 0.818 | NA | NA | 0.528 | NA | NA |
Tumor size: ≤ 6 cm vs >6 cm | 0.000 | 2.336 (1.114-4.897) | 0.025 | 0.000 | 3.790 (1.321-10.874) | 0.013 |
Tumor differentiation: well/moderate vs poor/undifferentiated | 0.589 | NA | NA | 0.000 | 6.426 (2.008-20.570) | 0.002 |
Lymph node metastasis: yes vs no | 0.000 | 2.256 (1.052-4.837) | 0.037 | 0.000 | 10.282 (3.343-31.620) | 0.000 |
Histological grade: I / II vs III | 0.001 | 3.743 (1.285-10.902) | 0.016 | 0.062 | NA | NA |
Node stage: N0 vs N1 vs N2 | 0.000 | 1.734 (1.087-2.765) | 0.021 | 0.000 | NA | NA |
TNM: I vs II vs III-IV | 0.018 | NA | NA | 0.016 | NA | NA |
DSCR1: negative vs positive | 0.001 | 0.355 (0.171-0.738) | 0.047 | 0.021 | NA | NA |