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Table 2 Comparison of patients’ characteristics between patients with neoadjuvant chemotherapy and without neoadjuvant chemotherapy

From: Efficacy of upfront hepatectomy without neoadjuvant chemotherapy for resectable colorectal liver metastasis

 

NAC (–) (n = 30)

NAC (+) (n = 58)

P-value

Male sex

21 (72%)

42 (71%)

0.904

Age (years)

73.5 (35–86)

69 (48–85)

0.026

BMI (kg/m2)

22 (16–34)

23 (15–30)

0.940

Location (colon)

11 (38%)

30 (51%)

0.254

Location (right side)

3 (10%)

9 (16%)

0.585

Timing of liver metastasis (synchronous)

13 (43%)

29 (50%)

0.703

Synchronous lung metastasis

0

5 (9%)

0.128

Tumor number (multiple)

14 (47%)

29 (50%)

0.938

Tumor number

1.5 (1–7)

1 (1–15)

0.521

CEA

13.9 (2–1224)

5.25 (1.2–111.1)

0.011

CA19-9

12.5 (2–642)

10.5 (2–2587.8)

0.989

Primary tumor differentiation (well)

   

N 1

15 (50%)

46 (79%)

0.012

Ly 1

14 (47%)

45 (78%)

0.009

Beppu’s nomogram score 6 <

16 (53%)

38 (66%)

0.403

Beppu’s nomogram score > 10

5 (17%)

26 (45%)

0.013

Beppu’s nomogram score

  

0.092

Clavien-Dindo classification

3

11

0.372

Laparoscopic hepatectomy

12 (40%)

14 (24%)

0.088

Operation time

322 (86–596)

356 (127–727)

0.253

Intraoperative bleeding

205 (20–4000)

290 (20–3020)

0.379

PNI

46 (28–81)

46 (34–61)

0.605

NLR

2.5 (0.3–9.4)

1.9 (0.6–6.2)

0.154

GPS

6

13

0.949

mGPS

3

10

0.356

  1. Variables in bold are statistically significant (P < 0.05). Continuous variables are expressed as median (range). Qualitative variables are expressed as number (%).BMI body mass index, NAC neoadjuvant chemotherapy, NLR neutrophil-to-lymphocyte ratio, PNI prognostic nutritional index, GPS Glasgow prognostic score, mGPS modified Glasgow prognostic score, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9