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Table 2 Comparison of patients’ characteristics between patients with neoadjuvant chemotherapy and without neoadjuvant chemotherapy

From: Efficacy of upfront hepatectomy without neoadjuvant chemotherapy for resectable colorectal liver metastasis

  NAC (–) (n = 30) NAC (+) (n = 58) P-value
Male sex 21 (72%) 42 (71%) 0.904
Age (years) 73.5 (35–86) 69 (48–85) 0.026
BMI (kg/m2) 22 (16–34) 23 (15–30) 0.940
Location (colon) 11 (38%) 30 (51%) 0.254
Location (right side) 3 (10%) 9 (16%) 0.585
Timing of liver metastasis (synchronous) 13 (43%) 29 (50%) 0.703
Synchronous lung metastasis 0 5 (9%) 0.128
Tumor number (multiple) 14 (47%) 29 (50%) 0.938
Tumor number 1.5 (1–7) 1 (1–15) 0.521
CEA 13.9 (2–1224) 5.25 (1.2–111.1) 0.011
CA19-9 12.5 (2–642) 10.5 (2–2587.8) 0.989
Primary tumor differentiation (well)    
N 1 15 (50%) 46 (79%) 0.012
Ly 1 14 (47%) 45 (78%) 0.009
Beppu’s nomogram score 6 < 16 (53%) 38 (66%) 0.403
Beppu’s nomogram score > 10 5 (17%) 26 (45%) 0.013
Beppu’s nomogram score    0.092
Clavien-Dindo classification 3 11 0.372
Laparoscopic hepatectomy 12 (40%) 14 (24%) 0.088
Operation time 322 (86–596) 356 (127–727) 0.253
Intraoperative bleeding 205 (20–4000) 290 (20–3020) 0.379
PNI 46 (28–81) 46 (34–61) 0.605
NLR 2.5 (0.3–9.4) 1.9 (0.6–6.2) 0.154
GPS 6 13 0.949
mGPS 3 10 0.356
  1. Variables in bold are statistically significant (P < 0.05). Continuous variables are expressed as median (range). Qualitative variables are expressed as number (%).BMI body mass index, NAC neoadjuvant chemotherapy, NLR neutrophil-to-lymphocyte ratio, PNI prognostic nutritional index, GPS Glasgow prognostic score, mGPS modified Glasgow prognostic score, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9