Table 1 Results of univariate and multivariate analyses of the clinicopathological factors for recurrence-free survival rates
Factors | Univariate analysis | Multivariate analysis | |
|---|---|---|---|
N | 3 years (%) | P-value | |
Gender | |||
Male | 63 | 32.6 | - |
Female | 25 | 40.9 | 0.361 |
BMI | |||
< 23 | 39 | 35.9 | - |
≥ 23 | 49 | 34.4 | 0.910 |
Location | |||
Colon | 47 | 34.8 | - |
Rectum | 41 | 34.6 | 0.853 |
Location | |||
Right side | 12 | 15.0 | |
Left side | 67 | 37.2 | |
Transverse | 9 | 44.4 | 0.125 |
Timing of liver metastasis | |||
Metachronous | 46 | 39.4 | |
Synchronous | 42 | 30.7 | 0.190 |
Synchronous lung metastasis | |||
Absent | 83 | 35.0 | |
Present | 5 | 40.0 | 0.590 |
Number of tumors | |||
1 | 46 | 49.0 | |
2–4 | 28 | 20.8 | |
≥ 5 | 14 | 19.2 | 0.030 |
Largest tumor diameter | |||
< 5 cm | 73 | 34.1 | |
≥ 5 cm | 15 | 37.0 | 0.999 |
CEA level (before hepatectomy) | |||
< 5 ng/ml | 35 | 27.9 | |
≥ 5 ng/mL | 52 | 38.5 | 0.438 |
CA19-9 level (before hepatectomy) | |||
< 38 U/mL | 63 | 29.6 | |
≥ 38 U/mL | 24 | 49.7 | 0.759 |
Stage (primary tumor) | |||
I–III | 42 | 43.7 | |
IV | 46 | 27.3 | 0.041 |
Liver metastasis classification | |||
H1 | 55 | 47.6 | |
H2–3 | 28 | 19.9 | 0.013 |
Prognosis grade classification | |||
Grade A | 50 | 48.7 | |
Grade B, C | 32 | 17.3 | 0.005 |
Primary tumor differentiation | |||
Well-differentiated | 46 | 35.5 | |
Others | 42 | 34.5 | 0.775 |
lympatic invasion (primary tumor) | |||
Negative | 29 | 41.5 | |
Positive | 59 | 31.6 | 0.161 |
venous invasion (primary tumor) | |||
Negative | 59 | 43.1 | |
Positive | 29 | 19.9 | 0.021 |
N | |||
Negative | 27 | 42.3 | |
Positive | 61 | 31.3 | 0.057 |
Beppu’s nomogram score | |||
< 6 | 34 | 49.2 | |
≥ 6 | 54 | 26.5 | 0.027 1.994 (1.083–3.672) 0.027 |
Chemotherapy before hepatectomy | |||
Absent | 30 | 46.8 | |
Present | 58 | 29.4 | 0.029 1.962 (1.092–3.524) 0.024 |
Operative procedure | |||
Laparoscopic hepatectomy | 26 | 36.1 | |
Open hepatectomy | 62 | 34.3 | 0.493 |