Fig. 6

High hypoxia risk tended to an immunosuppressive microenvironment. a, b The heatmap displaying the expression of the gene set involved in the negative regulation of anti-tumor immunotherapy in the low and high hypoxia risk groups in the TCGA and GEO databases. c–g The expression levels of VEGFA, CXCL8, ICAM1, MICB, and HAVCR1 in high and low hypoxia risk groups. Correlation between the expression of VEGFA, CXCL8, ICAM1, MICB, and HAVCRI and hypoxia risk score. h–j The expression of genes that positively regulating T cells, dendritic cells, and MDSC cells in the low and high hypoxia risk groups.*P < 0.05, **P < 0.01, and ***P < 0.001