Table 1 Clinicopathologic features of the 131 patients at the time of surgery
Parameters | Total (n = 131) | UFS (n = 64) | NAC (n = 67) | NAC (GS) (n = 62) | P value (UFS v.s. NAC) | P value (UFS v.s. NAC (GS)) |
|---|---|---|---|---|---|---|
Median age (range) | 69 (43-90) | 69 (46-90) | 69 (43-84) | 68 (43-84) | 0.163 | 0.105 |
Sex | ||||||
 Male | 72 | 38 | 34 | 32 | 0.381 | 0.473 |
 Female | 59 | 26 | 33 | 30 | ||
Date of surgery | ||||||
 Before 2014 | 42 | 39 | 3 | 1 | < 0.001 | < 0.001 |
 2014 and later | 89 | 25 | 64 | 61 | ||
Tumor location | ||||||
 Head | 79 | 43 | 36 | 34 | 0.153 | 0.201 |
 Body and tail | 52 | 21 | 31 | 28 | ||
Tumor size | ||||||
 pT1 | 25 | 8 | 17 | 16 | 0.076 | 0.071 |
 pT2/pT3 | 106 | 56 | 50 | 46 | ||
Tumor size | ||||||
 pT1/pT2 | 113 | 55 | 58 | 54 | 1.000 | 1.000 |
 pT3 | 18 | 9 | 9 | 8 | ||
Differentiation grade | ||||||
 G1/G2 | 112 | 52 | 60 | 55 | 0.218 | 0.321 |
 G3/G4 | 19 | 12 | 7 | 7 | ||
Differentiation grade | ||||||
 G1 | 56 | 27 | 29 | 27 | 1.000 | 1.000 |
 G2/G3/G4 | 75 | 37 | 38 | 35 | ||
Microvascular invasion | ||||||
 Positive | 115 | 59 | 56 | 51 | 0.397 | 0.261 |
 Negative | 14 | 5 | 9 | 9 | ||
 Unknown | 2 | 0 | 2 | 2 |  |  |
Lymphatic permeation | ||||||
 Positive | 96 | 49 | 47 | 43 | 0.436 | 0.424 |
 Negative | 35 | 15 | 20 | 19 | ||
Perineural invasion | ||||||
 Positive | 111 | 56 | 55 | 50 | 0.470 | 0.336 |
 Negative | 20 | 8 | 12 | 12 | ||
Nodal metastasis | ||||||
 pN0 | 50 | 20 | 30 | 28 | 0.015 | 0.005 |
 pN1 | 57 | 26 | 31 | 30 | ||
 pN2 | 24 | 18 | 6 | 4 | ||
Distant metastasis | ||||||
 Yes | 5 | 5 | 0 | 0 | 0.026 | 0.058 |
 No | 126 | 59 | 67 | 62 | ||
TNM stage | ||||||
 I/II | 104 | 43 | 61 | 58 | 0.001 | < 0.001 |
 III/IV | 27 | 21 | 6 | 4 | ||
R0 resection | ||||||
 Yes | 80 | 35 | 45 | 44 | 0.156 | 0.067 |
 No | 51 | 29 | 22 | 18 | ||
R2 resection | ||||||
 Yes | 1 | 0 | 1 | 1 | 1.000 | 0.492 |
 No | 130 | 64 | 66 | 61 | ||
Surgery-related death | ||||||
 Yes | 2 | 2 | 0 | 0 | 0.237 | 0.496 |
 No | 129 | 62 | 67 | 62 | ||
Postoperative chemotherapy | ||||||
 Yes | 113 | 54 | 59 | 54 | 0.271 | 0.399 |
 No | 14 | 9 | 5 | 5 | ||
 Unknown | 4 | 1 | 3 | 3 |  |  |
Postoperative radiotherapy | ||||||
 Yes | 7 | 3 | 4 | 4 | 1.000 | 0.715 |
 No | 124 | 61 | 63 | 58 | ||