Fig. 2

Macroscopic and microscopic findings of the tumor. a Tumor size was 55×45×40 mm, and the cut surface showed a predominantly HCC component (inside yellow line) admixed with NEC component (inside red line). b The HCC lesion (left upper side) and the NEC lesion (right lower side) (H&E stain). The HCC lesion was immunohistochemically positive for glypican-3 (c) but negative for synaptophysin (d) and chromogranin A (e). The NEC lesion was negative for glypican-3 (c) but negative for synaptophysin (d) and chromogranin A (e). The Ki-67 labeling index was 80% in the NEC lesion (f)