Fig. 2From: The lobular neoplasia enigma: management and prognosis in a long follow-up case seriesA representative case of lobular neoplasia. Vacuum-assisted biopsy of a microcalcifications cluster classified as BI-RADS R5 (a). Histologic appearance of corresponding pleomorphic lobular carcinoma in situ with areas of comedo-necrosis and periductal infiltrating lymphocytes (hematoxylin and eosin staining) (b, × 100). Immunohistochemical analyses of p63 (c, × 150). Myoepithelial layer with internal control of normal breast tissue and E-cadherin showing almost complete absence of staining (d, × 100)Back to article page