Table 1 Demographic and clinicopathological characteristics of the study groups
Variable | Total (n=628; 100%) n (%) | PBMa (n=93; 14.8%) n (%) | PSBMb (n=147; 23.4%) n (%) | FBM populationc (n=388; 61.8%) n (%) |
|---|---|---|---|---|
Age at diagnosis | ||||
Median (range) | 61 (2–92) | 69 (31–89) | 64 (2–92) | 58 (5–91) |
< 60 | 299 (47.61) | 24 (25.81) | 57 (38.78) | 218 (56.19) |
≥ 60 | 329 (52.39) | 69 (74.19) | 90 (61.22) | 170 (43.81) |
Sex | ||||
w | 330 (52.55) | 33 (35.48) | 73 (49.66) | 224 (57.73) |
m | 298 (47.45) | 60 (64.52) | 74 (50.34) | 164 (42.27) |
Tumor grade | ||||
1 | 33 (6.03) | 9 (11.11) | 3 (2.33) | 21 (6.23) |
2 | 295 (53.93) | 42 (51.85) | 62 (48.06) | 191 (56.68) |
3 | 219 (40.04) | 30 (37.04) | 64 (49.61) | 125 (37.09) |
Tumor type | ||||
Breast | 185 (29.46) | 10 (10.75) | 26 (17.69) | 149 (36.40) |
Lung | 158 (25.16) | 44 (47.31) | 70 (47.62) | 44 (11.34) |
Prostate | 50 (7.96) | 13 (13.98) | 8 (5.44) | 29 (7.47) |
Gastrointestinal | 65 (10.35) | 9 (9.68) | 8 (5.44) | 48 (12.37) |
Genitourinary | 32 (5.10) | 2 (2.15) | 6 (4.08) | 24 (6.19) |
Head and neck | 29 (4.62) | 3 (3.23) | 8 (5.44) | 18 (4.64) |
Melanoma | 11 (1.75) | 1 (1.08) | 1 (0.68) | 9 (2.32) |
Sarcoma | 33 (5.25) | 4 (4.30) | 7 (4.76) | 22 (5.67) |
Renal | 65 (10.35) | 7 (7.53) | 13 (8.84) | 45 (11.6) |
Metastasis characteristics | ||||
Osteoblastic | 50 (8.06) | 5 (5.38) | 7 (4.76) | 38 (10.00) |
Grade 1 | 5 | 2 | 0 | 3 |
Grade 2 | 22 | 3 | 2 | 17 |
Grade 3 | 17 | 0 | 3 | 14 |
Osteolytic | 448 (72.26) | 67 (72.04) | 112 (76.19) | 269 (70.79) |
Grade 1 | 15 | 2 | 2 | 11 |
Grade 2 | 200 | 31 | 42 | 127 |
Grade 3 | 172 | 26 | 8 | 93 |
Mixed | 122 (19.68) | 21 (22.58) | 28 (19.05) | 73 (19.21) |
Grade 1 | 12 | 5 | 1 | 6 |
Grade 2 | 72 | 8 | 18 | 46 |
Grade 3 | 29 | 4 | 53 | 17 |
Metastasis localization | ||||
Spine | 145 (23.09) | 20 (21.51) | 38 (25.85) | 87 (22.42) |
Spine+pelvis+other | 227 (36.15) | 44 (47.31) | 58 (39.46) | 125 (32.22) |
Spine+other | 83 (13.22) | 8 (8.60) | 21 (14.29) | 54 (13.92) |
Pelvis | 32 (5.10) | 1 (1.08) | 7 (4.76) | 24 (6.19) |
Pelvis+other | 36 (5.73) | 5 (5.38) | 7 (4.76) | 24 (6.19) |
Other | 105 (16.72) | 15 (16.13) | 16 (10.88) | 74 (19.07) |
Upper extremity | 13 | 2 | 2 | 9 |
Lower extremity | 45 | 8 | 5 | 32 |
Upper extremity+lower extremity | 3 | - | 1 | 2 |
Upper extremity+lower extremity+skull | 1 | - | - | 1 |
Upper extremity+skull | 1 | - | - | 1 |
Upper extremity+rib | 4 | 1 | - | 3 |
Lower extremity+skull | 1 | - | - | 1 |
Lower extremity+rib | 1 | - | - | 1 |
Sternum+rib | 1 | - | - | 1 |
Rib | 1 | - | 1 | - |
Clavicula | 1 | - | - | 1 |
Scapula | 1 | - | - | 1 |
Multiple localizations | 32 | 4 | 7 | 21 |
Complications | ||||
Fractures without neurological complications | 315 (50.16) | 47 (50.54) | 76 (51.70) | 192 (49.48) |
Fracture with neurological complications | 62 (9.87) | 9 (9.68) | 11 (7.48) | 42 (10.82) |
Neurological complications without fracture | 32 (5.10) | 7 (7.53) | 7 (4.76) | 18 (4.64) |
No complications | 219 (34.87) | 30 (32.26) | 53 (36.05) | 136 (35.05) |
Distribution of fracturesd | ||||
Fractures | 446 | 62 | 112 | 272 |
Trunk | 320 | 44 | 89 | 187 |
Spine | 247 | 38 | 64 | 145 |
With neurological deficit | 31 | 10 | 4 | 17 |
Paraplegia | 11 | 3 | 2 | 6 |
Without neurological deficit | 216 | 28 | 60 | 128 |
Pelvis | 45 | 3 | 17 | 25 |
Other | 28 | 3 | 8 | 17 |
Extremity | 126 | 18 | 23 | 85 |
Operative treatment of fracturese | ||||
Yes | 203 | 39 | 29 | 135 |
No | 174 | 48 | 27 | 99 |