Fig. 5
From: miR-378a-5p inhibits the proliferation of colorectal cancer cells by downregulating CDK1
CDK1 stimulates the proliferation and migration of CRC cells. a CDK1 expression in NCM460, SW620, HCT116, HT-29, and SW480 cells determined by qPCR. b/c The silencing efficiency of the three siRNAs detected using Western blot analysis. d The silencing or overexpression efficiency of CDK1 was assessed by qPCR as well as Western blotting. e Relative CRC cell growth rates at 12 h, 24 h, 36 h, 48 h, and 60 h after knockdown or upregulation of CDK1 were measured using a CCK-8 assay. f Transwell assays were conducted to assess how CDK1 overexpression or knockdown affected the migration of CRC cells. **p < 0.01; ***p < 0.001