Fig. 4
From: miR-378a-5p inhibits the proliferation of colorectal cancer cells by downregulating CDK1
CDK1, a miR-378a-5p target gene, is overexpressed in CRC. a Target genes of miR-378a-5p were predicted using TargetScan and RNAhybrid. b A luciferase reporter assay was conducted to verify the binding association of miR-378a-5p with CDK1. c Western blotting for CDK1 protein levels following miR-378a-5p mimic/inhibitor transfection. d TCGA database analysis of CDK1 expression in CRC. e CDK1 expression in 22 paired CRC tissues and tumor-adjacent tissues measured by qPCR. f Kaplan-Meier survival analysis of the effect of CDK1 levels on the prognosis of CRC patients. g Negative, weakly positive, medium positive, and strongly positive results of CDK1 expression in CRC tissues determined by IHC. **p < 0.01; ***p < 0.001