Fig. 3

miR-378a-5p promotes colorectal cell apoptosis and inhibits tumor growth in vivo. a Flow cytometry apoptosis experiments were used to measure the apoptosis rate of HT-29 and SW480 cells. b Subcutaneous injection of HT-29 cells stably transfected with control lentivirus and miR-378a-5p lentivirus into the armpit of nude mice. c Nude mice were sacrificed 15 days later, and tumors were collected and recorded. d A vernier caliper was used to measure the tumor volume every 3 days (n = 4) to draw a tumor growth curve. e Xenograft tumor weight of miR-378a-5p-overexpressing (miR-378a-5p lentivirus) HT-29 cells and control (control lentivirus) HT-29 cells in a xenograft model (n = 4). f qRT-PCR was used to detect the relative expression of miR-378a-5p in xenograft tumor tissues, and the data are expressed as the mean ± standard deviation, n = 4 for each group. **p < 0.01; ***p < 0.001