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Table 2 Univariate analysis and multivariate Cox regression analysis of clinical factors influencing overall survival outcomes in the training cohort

From: The preoperative prognostic value of the radiomics nomogram based on CT combined with machine learning in patients with intrahepatic cholangiocarcinoma

Variable Univariate analysis, p value Multivariate analysis, HR (95% CI) p value
Sex, male 0.238   
Age, years 0.148   
Hypertension 0.804   
Diabetes 0.334   
Hepatitis B 0.022   0.324
Liver cirrhosis 0.032   0.015
 Absent   ref  
 Present   2.227 (1.169–4.242)  
Hypersplenism 0.888   
ALT, IU/L 0.582   
AST, IU/L 0.750   
ALB, g/L 0.650   
TBIL, μmol/L 0.831   
PT, s 0.247   
INR 0.480   
AFP level, ng/mL 0.696   
CA 125 level, U/mL 0.083   0.839
CA 19-9 level 0.003   < 0.001
 < 35 U/mL   ref  
 ≥ 35 U/mL   3.984 (2.146–7.407)  
CEA level 0.172   
Tumor size 0.007   0.006
 ≤ 5 cm   ref  
 > 5 cm   2.293 (1.263–4.167)  
Differentiation 0.409   
  1. Abbreviations: HR Hazard ratio, ALT Alanine aminotransferase, AST Aspartate aminotransferase, ALB Albumin, TBIL Total bilirubin, PT Prothrombin time, INR International normalized ratio, AFP Alpha fetoprotein, CA Carbohydrate antigen, CEA Carcinoembryonic antigen, ref Reference