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Table 1 Baseline demographic and related clinical characteristics of patients diagnosed with colorectal cancer

From: Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

Subject characteristics Total distant metastases (N = 204,595) Liver met (N = 203,998) Lung met (N = 203,138) Bone met (N = 203,178) Brain met (N = 203,082)
With met (N = 34,933, 17.07%) Without met (N = 169,662, 82.93%) With liver met (N = 31,288, 15.34%) Without liver met (N = 172,710, 84.66%) With lung met (N = 10,598, 5.22%) Without lung met (N = 192,540, 94.78%) With bone met (N = 2553, 1.26%) Without none met (N = 200,625, 98.74%) With brain met (N = 587, 0.29%) Without brain met (N = 202,495, 99.71%)
Age (years)
 ≤ 50 5936 (18.6) 18506 (81.4) 5391 (16.9) 26432 (83.1) 1587 (5.0) 30130 (95.0) 431 (1.4) 31293 (98.6) 80 (0.3) 31637 (99.7)
 51–60 8382 (17.9) 38424 (82.1) 7635 (16.3) 39074 (83.7) 2517 (5.4) 44034 (94.6) 637 (1.4) 45918 (98.6) 161 (0.3) 46361 (99.7)
 61–70 9035 (17.3) 43185 (82.7) 8076 (15.5) 44002 (84.5) 2828 (5.4) 49063 (94.6) 698 (1.3) 51197 (98.7) 178 (0.3) 51707 (99.7)
 71–80 6460 (15.7) 34737 (84.3) 5702 (13.9) 35363 (86.1) 2088 (5.1) 38790 (94.9) 476 (1.2) 40411 (98.8) 101 (0.2) 40761 (99.8)
 81–90 4269 (15.5) 23355 (84.5) 3750 (13.6) 23758 (86.4) 1319 (4.8) 26010 (95.2) 252 (0.9) 27104 (99.1) 59 (0.2) 27275 (99.8)
 ≥ 91 851 (17.5) 4007 (82.5) 734 (15.2) 4081 (84.8) 259 (5.4) 4513 (94.6) 59 (1.2) 4702 (98.8) 8 (0.2) 4754 (99.8)
Sex
 Female 15660 (16.0) 82447 (84.0) 13895 (14.2) 83937 (85.8) 4855 (5.0) 92556 (95.0) 1022 (1.0) 96411 (99.0) 279 (0.3) 97106 (99.7)
 Male 19273 (18.1) 87215 (81.9) 17393 (16.4) 88773 (83.6) 5743 (5.4) 99984 (94.6) 1531 (1.4) 104214 (98.6) 308 (0.3) 105389 (99.7)
Race
 White 26234 (16.7) 130803 (83.3) 23459 (15.0) 133131 (85.0) 7795 (5.0) 148082 (95.0) 1906 (1.2) 154045 (98.8) 474 (0.3) 155391 (99.7)
 Black 5400 (21.1) 20177 (78.9) 4917 (19.3) 20580 (80.7) 1702 (6.7) 23721 (93.3) 402 (1.6) 25019 (98.4) 68 (0.3) 25353 (99.7)
 Othersa 3205 (16.1) 16684 (83.9) 2827 (14.3) 16995 (85.7) 1078 (5.5) 18677 (94.5) 239 (1.2) 19484 (98.8) 45 (0.2) 19668 (99.8)
 Unknown 94 (4.5) 1998 (95.5) 85 (4.1) 2004 (95.9) 23 (1.1) 2060 (98.9) 6 (0.3) 2077 (99.7) 0 (0.0) 2083 (100.0)
Marital status  
 Unmarriedb 16189 (18.7) 70408 (81.3) 14428 (16.7) 71859 (83.3) 5136 (6.0) 80725 (94.0) 1190 (1.4) 84657 (98.6) 276 (0.3) 85517 (99.7)
 Married 16944 (16.2) 87836 (83.8) 15277 (14.6) 89255 (85.4) 4884 (4.7) 99287 (95.3) 1231 (1.2) 102978 (98.8) 282 (0.3) 103888 (99.7)
 Unknown 1800 (13.6) 11418 (86.4) 1583 (12.0) 11596 (88.0) 578 (4.4) 12528 (95.6) 132 (1.0) 12990 (99.0) 29 (0.2) 13090 (99.8)
Insurance status
 Insured 27152 (16.0) 142570 (84.0) 24360 (14.4) 144894 (85.6) 8087 (4.8) 160490 (95.2) 1922 (1.1) 166706 (98.9) 452 (0.3) 168103 (99.7)
 Uninsured 1736 (25.3) 5127 (74.7) 1558 (22.8) 5281 (77.2) 589 (8.6) 6229 (91.4) 137 (2.0) 6687 (98.0) 104 (0.4) 27597 (99.6)
 Any Medic aid 6045 (21.6) 21965 (78.4) 5370 (19.2) 22535 (80.8) 1922 (6.9) 25821 (93.1) 494 (1.8) 27232 (98.2) 31 (0.5) 6795 (99.5)
Site
 Cecum 5203 (17.2) 25033 (82.8) 4811 (16.0) 25336 (84.0) 1341 (4.5) 28714 (95.5) 321 (1.1) 29747 (98.9) 86 (0.3) 29973 (99.7)
 Appendix 280 (4.4) 6022 (95.6) 238 (3.8) 6043 (96.2) 48 (0.8) 6232 (99.2) 29 (0.5) 6255 (99.5) 3 (0.0) 6282 (100.0)
 Ascending colon 3914 (14.4) 23235 (85.6) 3585 (13.2) 23495 (86.8) 1001 (3.7) 25976 (96.3) 222 (0.8) 26750 (99.2) 73 (0.3) 26897 (99.7)
 Hepatic flexure 1051 (17.0) 5144 (83.0) 964 (15.6) 5214 (84.4) 285 (4.6) 5863 (95.4) 67 (1.1) 6082 (98.9) 20 (0.3) 6121 (99.7)
 Transverse colon 1837 (14.7) 10691 (85.3) 1687 (13.5) 10811 (86.5) 432 (3.5) 12011 (96.5) 102 (0.8) 12348 (99.2) 27 (0.2) 12425 (99.8)
 Splenic flexure 749 (17.9) 3441 (82.1) 701 (16.8) 3476 (83.2) 170 (4.1) 3993 (95.9) 27 (0.6) 4133 (99.4) 4 (0.1) 4160 (99.9)
 Descending colon 1374 (16.2) 7127 (83.8) 1256 (14.8) 7229 (85.2) 355 (4.2) 8101 (95.8) 71 (0.8) 8389 (99.2) 18 (0.2) 8444 (99.8)
 Sigmoid colon 7212 (18.1) 32646 (81.9) 6625 (16.7) 33135 (83.3) 1999 (5.0) 37616 (95.0) 448 (1.1) 39172 (98.9) 93 (0.2) 39511 (99.8)
 Rectosigmoid junction 3135 (20.3) 12289 (79.7) 2804 (18.2) 12586 (81.8) 1044 (6.8) 14287 (93.2) 231 (1.5) 15097 (98.5) 54 (0.4) 15269 (99.6)
 Rectum 7098 (14.8) 40835 (85.2) 5905 (12.3) 41921 (87.7) 2898 (6.1) 44762 (93.9) 690 (1.4) 46988 (98.6) 117 (0.2) 47534 (99.8)
 Large intestinec 3080 (49.1) 3199 (50.9) 2712 (43.9) 3464 (56.1) 1025 (17.1) 4985 (82.9) 345 (5.7) 5664 (94.3) 92 (1.5) 5879 (98.5)
Histological grade
 Grade I 1420 (6.8) 19577 (93.2) 1253 (6.0) 19717 (94.0) 440 (2.1) 20502 (97.9) 88 (0.4) 20856 (99.6) 16 (0.1) 20924 (99.9)
 Grade II 16498 (13.7) 103978 (86.3) 14866 (12.4) 105375 (87.6) 4796 (4.0) 115175 (96.0) 824 (0.7) 119122 (99.3) 208 (0.2) 119707 (99.8)
 Grade III 5496 (20.4) 21404 (79.6) 4889 (18.2) 21927 (81.8) 1377 (5.2) 25303 (94.8) 497 (1.9) 26209 (98.1) 119 (0.4) 26569 (99.6)
 Grade IV 1037 (19.0) 4432 (81.0) 939 (17.2) 4514 (82.8) 224 (4.1) 5206 (95.9) 79 (1.5) 5353 (98.5) 18 (0.3) 5416 (99.7)
 Unknown 10482 (34.1) 20271 (65.9) 9341 (30.6) 21177 (69.4) 3761 (12.5) 26354 (87.5) 1065 (3.5) 29085 (96.5) 226 (0.8) 29879 (99.2)
Lymphatic metastasis
 N0 11445 (9.6) 107837 (90.4) 10133 (8.5) 108992 (91.5) 3631 (3.1) 115298 (96.9) 868 (0.7) 118114 (99.3) 194 (0.2) 118769 (99.8)
 N1 11055 (22.2) 38747 (77.8) 9945 (20.0) 39748 (80.0) 3435 (6.9) 46066 (93.1) 751 (1.5) 48781 (98.5) 163 (0.3) 49335 (99.7)
 N2 7034 (27.8) 18231 (72.2) 6412 (25.5) 18759 (74.5) 1609 (6.4) 23474 (93.6) 376 (1.5) 24715 (98.5) 90 (0.4) 24988 (99.6)
 Unknown 5399 (52.7) 4847 (47.3) 4798 (47.9) 5211 (52.1) 1923 (20.0) 7702 (80.0) 558 (5.8) 9015 (94.2) 140 (1.5) 9403 (98.5)
T stage
 T1 3267 (8.7) 34237 (91.3) 2913 (7.8) 34547 (92.2) 1121 (3.0) 36266 (97.0) 281 (0.8) 37113 (99.2) 57 (0.2) 37333 (99.8)
 T2 735 (3.2) 21981 (96.8) 644 (2.8) 22055 (97.2) 175 (0.8) 22522 (99.2) 49 (0.2) 22651 (99.8) 20 (0.1) 22680 (99.9)
 T3 10612 (12.5) 74390 (87.5) 9512 (11.2) 75366 (88.8) 2627 (3.1) 82120 (96.9) 457 (0.5) 84308 (99.5) 133 (0.2) 84605 (99.8)
 T4 7962 (25.7) 23077 (74.3) 7103 (23.0) 23806 (77.0) 2218 (7.2) 28548 (92.8) 527 (1.7) 30266 (98.3) 102 (0.3) 30675 (99.7)
 Unknown 12357 (43.6) 15977 (56.4) 11116 (39.6) 16936 (60.4) 4457 (16.2) 23084 (83.8) 1239 (4.5) 26287 (95.5) 275 (1.0) 27202 (99.0)
CEA
 Negative 3499 (6.1) 54327 (93.9) 2892 (5.0) 54845 (95.0) 899 (1.6) 56789 (98.4) 209 (0.4) 57497 (99.6) 66 (0.1) 57629 (99.9)
 Positive 20199 (37.1) 34246 (62.9) 18426 (34.0) 35810 (66.0) 6325 (11.8) 47487 (88.2) 1488 (2.8) 52382 (97.2) 310 (0.6) 53497 (99.4)
 Unknown 11235 (12.2) 81089 (87.8) 9970 (10.8) 82055 (89.2) 3374 (3.7) 88264 (96.3) 856 (0.9) 90746 (99.1) 211 (0.2) 91369 (99.8)
  1. Met metastases, CEA carcinoembryonic antigen, NA not available
  2. aIncludes American Indian/Alaska Native and Asian or Pacific Islander
  3. bIncludes single, separated, widowed, and divorced
  4. cSites were unclear