Subject characteristics | Total distant metastases (N = 204,595) | Liver met (N = 203,998) | Lung met (N = 203,138) | Bone met (N = 203,178) | Brain met (N = 203,082) | |||||
---|---|---|---|---|---|---|---|---|---|---|
With met (N = 34,933, 17.07%) | Without met (N = 169,662, 82.93%) | With liver met (N = 31,288, 15.34%) | Without liver met (N = 172,710, 84.66%) | With lung met (N = 10,598, 5.22%) | Without lung met (N = 192,540, 94.78%) | With bone met (N = 2553, 1.26%) | Without none met (N = 200,625, 98.74%) | With brain met (N = 587, 0.29%) | Without brain met (N = 202,495, 99.71%) | |
Age (years) | ||||||||||
 ≤ 50 | 5936 (18.6) | 18506 (81.4) | 5391 (16.9) | 26432 (83.1) | 1587 (5.0) | 30130 (95.0) | 431 (1.4) | 31293 (98.6) | 80 (0.3) | 31637 (99.7) |
 51–60 | 8382 (17.9) | 38424 (82.1) | 7635 (16.3) | 39074 (83.7) | 2517 (5.4) | 44034 (94.6) | 637 (1.4) | 45918 (98.6) | 161 (0.3) | 46361 (99.7) |
 61–70 | 9035 (17.3) | 43185 (82.7) | 8076 (15.5) | 44002 (84.5) | 2828 (5.4) | 49063 (94.6) | 698 (1.3) | 51197 (98.7) | 178 (0.3) | 51707 (99.7) |
 71–80 | 6460 (15.7) | 34737 (84.3) | 5702 (13.9) | 35363 (86.1) | 2088 (5.1) | 38790 (94.9) | 476 (1.2) | 40411 (98.8) | 101 (0.2) | 40761 (99.8) |
 81–90 | 4269 (15.5) | 23355 (84.5) | 3750 (13.6) | 23758 (86.4) | 1319 (4.8) | 26010 (95.2) | 252 (0.9) | 27104 (99.1) | 59 (0.2) | 27275 (99.8) |
 ≥ 91 | 851 (17.5) | 4007 (82.5) | 734 (15.2) | 4081 (84.8) | 259 (5.4) | 4513 (94.6) | 59 (1.2) | 4702 (98.8) | 8 (0.2) | 4754 (99.8) |
Sex | ||||||||||
 Female | 15660 (16.0) | 82447 (84.0) | 13895 (14.2) | 83937 (85.8) | 4855 (5.0) | 92556 (95.0) | 1022 (1.0) | 96411 (99.0) | 279 (0.3) | 97106 (99.7) |
 Male | 19273 (18.1) | 87215 (81.9) | 17393 (16.4) | 88773 (83.6) | 5743 (5.4) | 99984 (94.6) | 1531 (1.4) | 104214 (98.6) | 308 (0.3) | 105389 (99.7) |
Race | ||||||||||
 White | 26234 (16.7) | 130803 (83.3) | 23459 (15.0) | 133131 (85.0) | 7795 (5.0) | 148082 (95.0) | 1906 (1.2) | 154045 (98.8) | 474 (0.3) | 155391 (99.7) |
 Black | 5400 (21.1) | 20177 (78.9) | 4917 (19.3) | 20580 (80.7) | 1702 (6.7) | 23721 (93.3) | 402 (1.6) | 25019 (98.4) | 68 (0.3) | 25353 (99.7) |
 Othersa | 3205 (16.1) | 16684 (83.9) | 2827 (14.3) | 16995 (85.7) | 1078 (5.5) | 18677 (94.5) | 239 (1.2) | 19484 (98.8) | 45 (0.2) | 19668 (99.8) |
 Unknown | 94 (4.5) | 1998 (95.5) | 85 (4.1) | 2004 (95.9) | 23 (1.1) | 2060 (98.9) | 6 (0.3) | 2077 (99.7) | 0 (0.0) | 2083 (100.0) |
Marital status | Â | |||||||||
 Unmarriedb | 16189 (18.7) | 70408 (81.3) | 14428 (16.7) | 71859 (83.3) | 5136 (6.0) | 80725 (94.0) | 1190 (1.4) | 84657 (98.6) | 276 (0.3) | 85517 (99.7) |
 Married | 16944 (16.2) | 87836 (83.8) | 15277 (14.6) | 89255 (85.4) | 4884 (4.7) | 99287 (95.3) | 1231 (1.2) | 102978 (98.8) | 282 (0.3) | 103888 (99.7) |
 Unknown | 1800 (13.6) | 11418 (86.4) | 1583 (12.0) | 11596 (88.0) | 578 (4.4) | 12528 (95.6) | 132 (1.0) | 12990 (99.0) | 29 (0.2) | 13090 (99.8) |
Insurance status | ||||||||||
 Insured | 27152 (16.0) | 142570 (84.0) | 24360 (14.4) | 144894 (85.6) | 8087 (4.8) | 160490 (95.2) | 1922 (1.1) | 166706 (98.9) | 452 (0.3) | 168103 (99.7) |
 Uninsured | 1736 (25.3) | 5127 (74.7) | 1558 (22.8) | 5281 (77.2) | 589 (8.6) | 6229 (91.4) | 137 (2.0) | 6687 (98.0) | 104 (0.4) | 27597 (99.6) |
 Any Medic aid | 6045 (21.6) | 21965 (78.4) | 5370 (19.2) | 22535 (80.8) | 1922 (6.9) | 25821 (93.1) | 494 (1.8) | 27232 (98.2) | 31 (0.5) | 6795 (99.5) |
Site | ||||||||||
 Cecum | 5203 (17.2) | 25033 (82.8) | 4811 (16.0) | 25336 (84.0) | 1341 (4.5) | 28714 (95.5) | 321 (1.1) | 29747 (98.9) | 86 (0.3) | 29973 (99.7) |
 Appendix | 280 (4.4) | 6022 (95.6) | 238 (3.8) | 6043 (96.2) | 48 (0.8) | 6232 (99.2) | 29 (0.5) | 6255 (99.5) | 3 (0.0) | 6282 (100.0) |
 Ascending colon | 3914 (14.4) | 23235 (85.6) | 3585 (13.2) | 23495 (86.8) | 1001 (3.7) | 25976 (96.3) | 222 (0.8) | 26750 (99.2) | 73 (0.3) | 26897 (99.7) |
 Hepatic flexure | 1051 (17.0) | 5144 (83.0) | 964 (15.6) | 5214 (84.4) | 285 (4.6) | 5863 (95.4) | 67 (1.1) | 6082 (98.9) | 20 (0.3) | 6121 (99.7) |
 Transverse colon | 1837 (14.7) | 10691 (85.3) | 1687 (13.5) | 10811 (86.5) | 432 (3.5) | 12011 (96.5) | 102 (0.8) | 12348 (99.2) | 27 (0.2) | 12425 (99.8) |
 Splenic flexure | 749 (17.9) | 3441 (82.1) | 701 (16.8) | 3476 (83.2) | 170 (4.1) | 3993 (95.9) | 27 (0.6) | 4133 (99.4) | 4 (0.1) | 4160 (99.9) |
 Descending colon | 1374 (16.2) | 7127 (83.8) | 1256 (14.8) | 7229 (85.2) | 355 (4.2) | 8101 (95.8) | 71 (0.8) | 8389 (99.2) | 18 (0.2) | 8444 (99.8) |
 Sigmoid colon | 7212 (18.1) | 32646 (81.9) | 6625 (16.7) | 33135 (83.3) | 1999 (5.0) | 37616 (95.0) | 448 (1.1) | 39172 (98.9) | 93 (0.2) | 39511 (99.8) |
 Rectosigmoid junction | 3135 (20.3) | 12289 (79.7) | 2804 (18.2) | 12586 (81.8) | 1044 (6.8) | 14287 (93.2) | 231 (1.5) | 15097 (98.5) | 54 (0.4) | 15269 (99.6) |
 Rectum | 7098 (14.8) | 40835 (85.2) | 5905 (12.3) | 41921 (87.7) | 2898 (6.1) | 44762 (93.9) | 690 (1.4) | 46988 (98.6) | 117 (0.2) | 47534 (99.8) |
 Large intestinec | 3080 (49.1) | 3199 (50.9) | 2712 (43.9) | 3464 (56.1) | 1025 (17.1) | 4985 (82.9) | 345 (5.7) | 5664 (94.3) | 92 (1.5) | 5879 (98.5) |
Histological grade | ||||||||||
 Grade I | 1420 (6.8) | 19577 (93.2) | 1253 (6.0) | 19717 (94.0) | 440 (2.1) | 20502 (97.9) | 88 (0.4) | 20856 (99.6) | 16 (0.1) | 20924 (99.9) |
 Grade II | 16498 (13.7) | 103978 (86.3) | 14866 (12.4) | 105375 (87.6) | 4796 (4.0) | 115175 (96.0) | 824 (0.7) | 119122 (99.3) | 208 (0.2) | 119707 (99.8) |
 Grade III | 5496 (20.4) | 21404 (79.6) | 4889 (18.2) | 21927 (81.8) | 1377 (5.2) | 25303 (94.8) | 497 (1.9) | 26209 (98.1) | 119 (0.4) | 26569 (99.6) |
 Grade IV | 1037 (19.0) | 4432 (81.0) | 939 (17.2) | 4514 (82.8) | 224 (4.1) | 5206 (95.9) | 79 (1.5) | 5353 (98.5) | 18 (0.3) | 5416 (99.7) |
 Unknown | 10482 (34.1) | 20271 (65.9) | 9341 (30.6) | 21177 (69.4) | 3761 (12.5) | 26354 (87.5) | 1065 (3.5) | 29085 (96.5) | 226 (0.8) | 29879 (99.2) |
Lymphatic metastasis | ||||||||||
 N0 | 11445 (9.6) | 107837 (90.4) | 10133 (8.5) | 108992 (91.5) | 3631 (3.1) | 115298 (96.9) | 868 (0.7) | 118114 (99.3) | 194 (0.2) | 118769 (99.8) |
 N1 | 11055 (22.2) | 38747 (77.8) | 9945 (20.0) | 39748 (80.0) | 3435 (6.9) | 46066 (93.1) | 751 (1.5) | 48781 (98.5) | 163 (0.3) | 49335 (99.7) |
 N2 | 7034 (27.8) | 18231 (72.2) | 6412 (25.5) | 18759 (74.5) | 1609 (6.4) | 23474 (93.6) | 376 (1.5) | 24715 (98.5) | 90 (0.4) | 24988 (99.6) |
 Unknown | 5399 (52.7) | 4847 (47.3) | 4798 (47.9) | 5211 (52.1) | 1923 (20.0) | 7702 (80.0) | 558 (5.8) | 9015 (94.2) | 140 (1.5) | 9403 (98.5) |
T stage | ||||||||||
 T1 | 3267 (8.7) | 34237 (91.3) | 2913 (7.8) | 34547 (92.2) | 1121 (3.0) | 36266 (97.0) | 281 (0.8) | 37113 (99.2) | 57 (0.2) | 37333 (99.8) |
 T2 | 735 (3.2) | 21981 (96.8) | 644 (2.8) | 22055 (97.2) | 175 (0.8) | 22522 (99.2) | 49 (0.2) | 22651 (99.8) | 20 (0.1) | 22680 (99.9) |
 T3 | 10612 (12.5) | 74390 (87.5) | 9512 (11.2) | 75366 (88.8) | 2627 (3.1) | 82120 (96.9) | 457 (0.5) | 84308 (99.5) | 133 (0.2) | 84605 (99.8) |
 T4 | 7962 (25.7) | 23077 (74.3) | 7103 (23.0) | 23806 (77.0) | 2218 (7.2) | 28548 (92.8) | 527 (1.7) | 30266 (98.3) | 102 (0.3) | 30675 (99.7) |
 Unknown | 12357 (43.6) | 15977 (56.4) | 11116 (39.6) | 16936 (60.4) | 4457 (16.2) | 23084 (83.8) | 1239 (4.5) | 26287 (95.5) | 275 (1.0) | 27202 (99.0) |
CEA | ||||||||||
 Negative | 3499 (6.1) | 54327 (93.9) | 2892 (5.0) | 54845 (95.0) | 899 (1.6) | 56789 (98.4) | 209 (0.4) | 57497 (99.6) | 66 (0.1) | 57629 (99.9) |
 Positive | 20199 (37.1) | 34246 (62.9) | 18426 (34.0) | 35810 (66.0) | 6325 (11.8) | 47487 (88.2) | 1488 (2.8) | 52382 (97.2) | 310 (0.6) | 53497 (99.4) |
 Unknown | 11235 (12.2) | 81089 (87.8) | 9970 (10.8) | 82055 (89.2) | 3374 (3.7) | 88264 (96.3) | 856 (0.9) | 90746 (99.1) | 211 (0.2) | 91369 (99.8) |