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Table 1 Baseline demographic and related clinical characteristics of patients diagnosed with colorectal cancer

From: Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

Subject characteristics

Total distant metastases (N = 204,595)

Liver met (N = 203,998)

Lung met (N = 203,138)

Bone met (N = 203,178)

Brain met (N = 203,082)

With met (N = 34,933, 17.07%)

Without met (N = 169,662, 82.93%)

With liver met (N = 31,288, 15.34%)

Without liver met (N = 172,710, 84.66%)

With lung met (N = 10,598, 5.22%)

Without lung met (N = 192,540, 94.78%)

With bone met (N = 2553, 1.26%)

Without none met (N = 200,625, 98.74%)

With brain met (N = 587, 0.29%)

Without brain met (N = 202,495, 99.71%)

Age (years)

 ≤ 50

5936 (18.6)

18506 (81.4)

5391 (16.9)

26432 (83.1)

1587 (5.0)

30130 (95.0)

431 (1.4)

31293 (98.6)

80 (0.3)

31637 (99.7)

 51–60

8382 (17.9)

38424 (82.1)

7635 (16.3)

39074 (83.7)

2517 (5.4)

44034 (94.6)

637 (1.4)

45918 (98.6)

161 (0.3)

46361 (99.7)

 61–70

9035 (17.3)

43185 (82.7)

8076 (15.5)

44002 (84.5)

2828 (5.4)

49063 (94.6)

698 (1.3)

51197 (98.7)

178 (0.3)

51707 (99.7)

 71–80

6460 (15.7)

34737 (84.3)

5702 (13.9)

35363 (86.1)

2088 (5.1)

38790 (94.9)

476 (1.2)

40411 (98.8)

101 (0.2)

40761 (99.8)

 81–90

4269 (15.5)

23355 (84.5)

3750 (13.6)

23758 (86.4)

1319 (4.8)

26010 (95.2)

252 (0.9)

27104 (99.1)

59 (0.2)

27275 (99.8)

 ≥ 91

851 (17.5)

4007 (82.5)

734 (15.2)

4081 (84.8)

259 (5.4)

4513 (94.6)

59 (1.2)

4702 (98.8)

8 (0.2)

4754 (99.8)

Sex

 Female

15660 (16.0)

82447 (84.0)

13895 (14.2)

83937 (85.8)

4855 (5.0)

92556 (95.0)

1022 (1.0)

96411 (99.0)

279 (0.3)

97106 (99.7)

 Male

19273 (18.1)

87215 (81.9)

17393 (16.4)

88773 (83.6)

5743 (5.4)

99984 (94.6)

1531 (1.4)

104214 (98.6)

308 (0.3)

105389 (99.7)

Race

 White

26234 (16.7)

130803 (83.3)

23459 (15.0)

133131 (85.0)

7795 (5.0)

148082 (95.0)

1906 (1.2)

154045 (98.8)

474 (0.3)

155391 (99.7)

 Black

5400 (21.1)

20177 (78.9)

4917 (19.3)

20580 (80.7)

1702 (6.7)

23721 (93.3)

402 (1.6)

25019 (98.4)

68 (0.3)

25353 (99.7)

 Othersa

3205 (16.1)

16684 (83.9)

2827 (14.3)

16995 (85.7)

1078 (5.5)

18677 (94.5)

239 (1.2)

19484 (98.8)

45 (0.2)

19668 (99.8)

 Unknown

94 (4.5)

1998 (95.5)

85 (4.1)

2004 (95.9)

23 (1.1)

2060 (98.9)

6 (0.3)

2077 (99.7)

0 (0.0)

2083 (100.0)

Marital status

 

 Unmarriedb

16189 (18.7)

70408 (81.3)

14428 (16.7)

71859 (83.3)

5136 (6.0)

80725 (94.0)

1190 (1.4)

84657 (98.6)

276 (0.3)

85517 (99.7)

 Married

16944 (16.2)

87836 (83.8)

15277 (14.6)

89255 (85.4)

4884 (4.7)

99287 (95.3)

1231 (1.2)

102978 (98.8)

282 (0.3)

103888 (99.7)

 Unknown

1800 (13.6)

11418 (86.4)

1583 (12.0)

11596 (88.0)

578 (4.4)

12528 (95.6)

132 (1.0)

12990 (99.0)

29 (0.2)

13090 (99.8)

Insurance status

 Insured

27152 (16.0)

142570 (84.0)

24360 (14.4)

144894 (85.6)

8087 (4.8)

160490 (95.2)

1922 (1.1)

166706 (98.9)

452 (0.3)

168103 (99.7)

 Uninsured

1736 (25.3)

5127 (74.7)

1558 (22.8)

5281 (77.2)

589 (8.6)

6229 (91.4)

137 (2.0)

6687 (98.0)

104 (0.4)

27597 (99.6)

 Any Medic aid

6045 (21.6)

21965 (78.4)

5370 (19.2)

22535 (80.8)

1922 (6.9)

25821 (93.1)

494 (1.8)

27232 (98.2)

31 (0.5)

6795 (99.5)

Site

 Cecum

5203 (17.2)

25033 (82.8)

4811 (16.0)

25336 (84.0)

1341 (4.5)

28714 (95.5)

321 (1.1)

29747 (98.9)

86 (0.3)

29973 (99.7)

 Appendix

280 (4.4)

6022 (95.6)

238 (3.8)

6043 (96.2)

48 (0.8)

6232 (99.2)

29 (0.5)

6255 (99.5)

3 (0.0)

6282 (100.0)

 Ascending colon

3914 (14.4)

23235 (85.6)

3585 (13.2)

23495 (86.8)

1001 (3.7)

25976 (96.3)

222 (0.8)

26750 (99.2)

73 (0.3)

26897 (99.7)

 Hepatic flexure

1051 (17.0)

5144 (83.0)

964 (15.6)

5214 (84.4)

285 (4.6)

5863 (95.4)

67 (1.1)

6082 (98.9)

20 (0.3)

6121 (99.7)

 Transverse colon

1837 (14.7)

10691 (85.3)

1687 (13.5)

10811 (86.5)

432 (3.5)

12011 (96.5)

102 (0.8)

12348 (99.2)

27 (0.2)

12425 (99.8)

 Splenic flexure

749 (17.9)

3441 (82.1)

701 (16.8)

3476 (83.2)

170 (4.1)

3993 (95.9)

27 (0.6)

4133 (99.4)

4 (0.1)

4160 (99.9)

 Descending colon

1374 (16.2)

7127 (83.8)

1256 (14.8)

7229 (85.2)

355 (4.2)

8101 (95.8)

71 (0.8)

8389 (99.2)

18 (0.2)

8444 (99.8)

 Sigmoid colon

7212 (18.1)

32646 (81.9)

6625 (16.7)

33135 (83.3)

1999 (5.0)

37616 (95.0)

448 (1.1)

39172 (98.9)

93 (0.2)

39511 (99.8)

 Rectosigmoid junction

3135 (20.3)

12289 (79.7)

2804 (18.2)

12586 (81.8)

1044 (6.8)

14287 (93.2)

231 (1.5)

15097 (98.5)

54 (0.4)

15269 (99.6)

 Rectum

7098 (14.8)

40835 (85.2)

5905 (12.3)

41921 (87.7)

2898 (6.1)

44762 (93.9)

690 (1.4)

46988 (98.6)

117 (0.2)

47534 (99.8)

 Large intestinec

3080 (49.1)

3199 (50.9)

2712 (43.9)

3464 (56.1)

1025 (17.1)

4985 (82.9)

345 (5.7)

5664 (94.3)

92 (1.5)

5879 (98.5)

Histological grade

 Grade I

1420 (6.8)

19577 (93.2)

1253 (6.0)

19717 (94.0)

440 (2.1)

20502 (97.9)

88 (0.4)

20856 (99.6)

16 (0.1)

20924 (99.9)

 Grade II

16498 (13.7)

103978 (86.3)

14866 (12.4)

105375 (87.6)

4796 (4.0)

115175 (96.0)

824 (0.7)

119122 (99.3)

208 (0.2)

119707 (99.8)

 Grade III

5496 (20.4)

21404 (79.6)

4889 (18.2)

21927 (81.8)

1377 (5.2)

25303 (94.8)

497 (1.9)

26209 (98.1)

119 (0.4)

26569 (99.6)

 Grade IV

1037 (19.0)

4432 (81.0)

939 (17.2)

4514 (82.8)

224 (4.1)

5206 (95.9)

79 (1.5)

5353 (98.5)

18 (0.3)

5416 (99.7)

 Unknown

10482 (34.1)

20271 (65.9)

9341 (30.6)

21177 (69.4)

3761 (12.5)

26354 (87.5)

1065 (3.5)

29085 (96.5)

226 (0.8)

29879 (99.2)

Lymphatic metastasis

 N0

11445 (9.6)

107837 (90.4)

10133 (8.5)

108992 (91.5)

3631 (3.1)

115298 (96.9)

868 (0.7)

118114 (99.3)

194 (0.2)

118769 (99.8)

 N1

11055 (22.2)

38747 (77.8)

9945 (20.0)

39748 (80.0)

3435 (6.9)

46066 (93.1)

751 (1.5)

48781 (98.5)

163 (0.3)

49335 (99.7)

 N2

7034 (27.8)

18231 (72.2)

6412 (25.5)

18759 (74.5)

1609 (6.4)

23474 (93.6)

376 (1.5)

24715 (98.5)

90 (0.4)

24988 (99.6)

 Unknown

5399 (52.7)

4847 (47.3)

4798 (47.9)

5211 (52.1)

1923 (20.0)

7702 (80.0)

558 (5.8)

9015 (94.2)

140 (1.5)

9403 (98.5)

T stage

 T1

3267 (8.7)

34237 (91.3)

2913 (7.8)

34547 (92.2)

1121 (3.0)

36266 (97.0)

281 (0.8)

37113 (99.2)

57 (0.2)

37333 (99.8)

 T2

735 (3.2)

21981 (96.8)

644 (2.8)

22055 (97.2)

175 (0.8)

22522 (99.2)

49 (0.2)

22651 (99.8)

20 (0.1)

22680 (99.9)

 T3

10612 (12.5)

74390 (87.5)

9512 (11.2)

75366 (88.8)

2627 (3.1)

82120 (96.9)

457 (0.5)

84308 (99.5)

133 (0.2)

84605 (99.8)

 T4

7962 (25.7)

23077 (74.3)

7103 (23.0)

23806 (77.0)

2218 (7.2)

28548 (92.8)

527 (1.7)

30266 (98.3)

102 (0.3)

30675 (99.7)

 Unknown

12357 (43.6)

15977 (56.4)

11116 (39.6)

16936 (60.4)

4457 (16.2)

23084 (83.8)

1239 (4.5)

26287 (95.5)

275 (1.0)

27202 (99.0)

CEA

 Negative

3499 (6.1)

54327 (93.9)

2892 (5.0)

54845 (95.0)

899 (1.6)

56789 (98.4)

209 (0.4)

57497 (99.6)

66 (0.1)

57629 (99.9)

 Positive

20199 (37.1)

34246 (62.9)

18426 (34.0)

35810 (66.0)

6325 (11.8)

47487 (88.2)

1488 (2.8)

52382 (97.2)

310 (0.6)

53497 (99.4)

 Unknown

11235 (12.2)

81089 (87.8)

9970 (10.8)

82055 (89.2)

3374 (3.7)

88264 (96.3)

856 (0.9)

90746 (99.1)

211 (0.2)

91369 (99.8)

  1. Met metastases, CEA carcinoembryonic antigen, NA not available
  2. aIncludes American Indian/Alaska Native and Asian or Pacific Islander
  3. bIncludes single, separated, widowed, and divorced
  4. cSites were unclear