Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery

Table 4 Univariate and multivariate analyses of predictive factors associated with disease-free survival in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy

		Univariate analysis			Multivariate analysis
Variable		HR	95% CI	p value	HR	95% CI	p value
Sex	Male vs. female	2.30	0.97–6.76	0.060
Age (years)	> 63 vs. ≤ 63	1.13	0.57–2.22	0.74
Histological type	Poor/mucinous vs. well/moderate	1.53	0.55–6.37	0.46
Pathological N stage	ypN(+) vs ypN(−)	3.78	1.88–8.07	0.00020	3.28	1.57–7.27	0.0014
Lymphatic invasion	2, 3 vs. 0, 1	1.54	0.78–3.07	0.21
Vascular invasion	2, 3 vs. 0, 1	2.84	1.43–5.79	0.0028	1.75	0.84–3.72	0.14
Radiation effect	Grades 2, 3 vs. 0–1	2.28	1.07–5.39	0.031	1.59	0.72–3.90	0.26
Radiation course	Short vs. long	1.25	0.58–2.52	0.55
Adjuvant chemotherapy	Yes vs. no	1.51	0.72–3.58	0.29
CA19-9	> 37.0 vs. ≤ 37.0 ng/ml	1.85	0.82–3.84	0.13
CEA	> 5 vs. ≤ 5 ng/ml	2.05	1.02–4.37	0.044	1.85	0.89–4.06	0.10
PLR	> 150 vs. ≤ 150	1.16	0.57–2.28	0.67
PNI	≤ 51 vs. > 51	1.56	0.79–3.21	0.20
mGPS	1, 2 vs. 0	1.03	0.41–2.25	0.94
GNRI	≤ 104.25 vs. > 104.25	2.65	1.33–5.42	0.0054	2.71	1.36–5.60	0.0047

Note: Parameters with p < 0.05 in the univariate analysis were used for the multivariate analysis
HR hazard ratio, CI confidence interval, CA19-9 carbohydrate antigen 19-9, CEA carcinoembryonic antigen, PLR platelet-lymphocyte ratio, PNI prognostic nutrition index, mGPS modified Glasgow Prognostic score, GNRI geriatric nutritional risk index

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